TY - JOUR T1 - Endovascular revascularization results in IMS III: intracranial ICA and M1 occlusions JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 795 LP - 802 DO - 10.1136/neurintsurg-2014-011318 VL - 7 IS - 11 AU - Thomas A Tomsick AU - Sharon D Yeatts AU - David S Liebeskind AU - Janice Carrozzella AU - Lydia Foster AU - Mayank Goyal AU - Ruediger von Kummer AU - Michael D Hill AU - Andrew M Demchuk AU - Tudor Jovin AU - Bernard Yan AU - Osama O Zaidat AU - Wouter Schonewille AU - Stefan Engelter AU - Renee Martin AU - Pooja Khatri AU - Judith Spilker AU - Yuko Y Palesch AU - Joseph P Broderick Y1 - 2015/11/01 UR - http://jnis.bmj.com/content/7/11/795.abstract N2 - Background Interventional Management of Stroke III did not show that combining IV recombinant tissue plasminogen activator (rt-PA) with endovascular therapies (EVTs) is better than IV rt-PA alone.Objective To report efficacy and safety results for EVT of intracranial internal carotid artery (ICA) and middle cerebral artery trunk (M1) occlusion.Methods Five revascularization methods for persistent occlusions after IV rt-PA treatment were evaluated for prespecified primary and secondary endpoints, after accounting for differences in key baselines variables using propensity scores. Revascularization was scored using the arterial occlusive lesion (AOL) and the modified Thrombolysis in Cerebral Ischemia (mTICI) scores.Results EVT of 200 subjects with intracranial ICA or M1 occlusion resulted in 81.5% AOL 2–3 recanalization, in addition to 76% mTICI 2–3 and 42.5% mTICI 2b–3 reperfusion. Adverse events included symptomatic intracranial hemorrhage (SICH) (8.0%), vessel perforations (1.5%), and new emboli (14.9%). EVT techniques used were standard microcatheter n=51; EKOS n=14; Merci n=77; Penumbra n=39; Solitaire n=4; multiple n=15. Good clinical outcome was associated with both TICI 2–3 and TICI 2b–3 reperfusion. Neither modified Rankin scale (mRS) 0–2 (28.5%), nor 90-day mortality (28.5%), nor asymptomatic ICH (36.0%) differed among revascularization methods after propensity score adjustment for subjects with intracranial ICA or M1 occlusion.Conclusions Good clinical outcome was associated with good reperfusion for ICA and M1 occlusion. No significant differences in efficacy or safety among revascularization methods were demonstrated after adjustment. Lack of high-quality reperfusion, adverse events, and prolonged time to treatment contributed to lower-than-expected mRS 0–2 outcomes and study futility compared with IV rt-PA.Trial registration number NCT00359424. ER -