TY - JOUR T1 - Catheter based selective hypothermia reduces stroke volume during focal cerebral ischemia in swine JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 418 LP - 422 DO - 10.1136/neurintsurg-2014-011562 VL - 8 IS - 4 AU - Thomas K Mattingly AU - Lynn M Denning AU - Karen L Siroen AU - Barb Lehrbass AU - Pablo Lopez-Ojeda AU - Larry Stitt AU - David M Pelz AU - Sumit Das AU - Lee-Cyn Ang AU - Donald H Lee AU - Stephen P Lownie Y1 - 2016/04/01 UR - http://jnis.bmj.com/content/8/4/418.abstract N2 - Background Total body hypothermia is an established neuroprotectant in global cerebral ischemia. The role of hypothermia in acute ischemic stroke remains uncertain. Selective application of hypothermia to a region of focal ischemia may provide similar protection with more rapid cooling and elimination of systemic side effects. We studied the effect of selective endovascular cooling in a focal stroke model in adult domestic swine.Methods After craniotomy under general anesthesia, a proximal middle cerebral artery branch was occluded for 3 h, followed by 3 h of reperfusion. In half of the animals, selective hypothermia was induced during reperfusion using a dual lumen balloon occlusion catheter placed in the ipsilateral common carotid artery. Following reperfusion, the animals were sacrificed. Brain MRI and histology were evaluated by experts who were blinded to the intervention.Results 25 animals were available for analysis. Using selective hypothermia, hemicranial temperature was successfully cooled to a mean of 26.5°C. Average time from start of perfusion to attainment of moderate hypothermia (<30°C) was 25 min. Mean MRI stroke volumes were significantly reduced by selective cooling (0.050±0.059 control, 0.005±0.011 hypothermia (ratio stroke:hemisphere volume) (p=0.046). Stroke pathology volumes were reduced by 42% compared with controls (p=0.256).Conclusions Selective moderate hypothermia was rapidly induced using endovascular techniques in a clinically realistic swine stroke model. A significant reduction in stroke volume on MRI was observed. Endovascular selective hypothermia can provide neuroprotection within time frames relevant to acute ischemic stroke treatment. ER -