TY - JOUR T1 - Determination of a shear rate threshold for thrombus formation in intracranial aneurysms JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 853 LP - 858 DO - 10.1136/neurintsurg-2015-011737 VL - 8 IS - 8 AU - Daniel Ribeiro de Sousa AU - Carolina Vallecilla AU - Kamil Chodzynski AU - Ricardo Corredor Jerez AU - Orestis Malaspinas AU - Omer Faruk Eker AU - Rafik Ouared AU - Luc Vanhamme AU - Alexandre Legrand AU - Bastien Chopard AU - Guy Courbebaisse AU - Karim Zouaoui Boudjeltia Y1 - 2016/08/01 UR - http://jnis.bmj.com/content/8/8/853.abstract N2 - Background Particular intra-aneurysmal blood flow conditions, created naturally by the growth of an aneurysm or induced artificially by implantation of a flow diverter stent (FDS), can potentiate intra-aneurysmal thrombosis. The aim of this study was to identify hemodynamic indicators, relevant to this process, which could be used as a prediction of the success of a preventive endovascular treatment.Method A cross sectional study on 21 patients was carried out to investigate the possible association between intra-aneurysmal spontaneous thrombus volume and the dome to neck aspect ratio (AR) of the aneurysm. The mechanistic link between these two parameters was further investigated through a Fourier analysis of the intra-aneurysmal shear rate (SR) obtained by computational fluid dynamics (CFD). This analysis was first applied to 10 additional patients (4 with and 6 without spontaneous thrombosis) and later to 3 patients whose intracranial aneurysms only thrombosed after FDS implantation.Results The cross sectional study revealed an association between intra-aneurysmal spontaneous thrombus volume and the AR of the aneurysm (R2=0.67, p<0.001). Fourier analysis revealed that in cases where thrombosis occurred, the SR harmonics 0, 1, and 2 were always less than 25/s, 10/s, and 5/s, respectively, and always greater than these values where spontaneous thrombosis was not observed.Conclusions Our study suggests the existence of an SR threshold below which thrombosis will occur. Therefore, by analyzing the SR on patient specific data with CFD techniques, it may be potentially possible to predict whether or the intra-aneurysmal flow conditions, after FDS implantation, will become prothrombotic. ER -