TY - JOUR T1 - Different risk factors for poor outcome between patients with positive and negative susceptibility vessel sign JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 1001 LP - 1005 DO - 10.1136/neurintsurg-2015-011999 VL - 8 IS - 10 AU - Shenqiang Yan AU - Keqin Liu AU - Lusha Tong AU - Yannan Yu AU - Sheng Zhang AU - Min Lou Y1 - 2016/10/01 UR - http://jnis.bmj.com/content/8/10/1001.abstract N2 - Purpose The absence of the susceptibility vessel sign (negative SVS) on gradient-recalled echo or susceptibility-weighted imaging (SWI) in thrombolytic therapy has not been well studied. Since positive and negative SVS may have different components, we aimed to investigate the difference in risk factors for clinical outcome between patients with positive and negative SVS.Methods We retrospectively examined clinical and imaging data from 85 consecutive patients with acute ischemic stroke with middle cerebral artery occlusion who underwent SWI before intravenous thrombolysis (IVT). We then examined the predictors of negative SVS and the risk factors for a poor outcome (defined as modified Rankin Scale score ≥3) 3 months after IVT in subgroup analysis.Results Multivariate regression analysis indicated that previous antiplatelet use (OR 0.076; 95% CI 0.007 to 0.847; p=0.036) and shorter time from onset to treatment (OR 1.051; 95% CI 1.003 to 1.102; p=0.037) were inversely associated with poor outcome in patients with negative SVS, while higher baseline National Institutes of Health Stroke Scale (NIHSS) score was associated with poor outcome in patients with positive SVS (OR 1.222; 95% CI 1.084 to 1.377; p=0.001).Conclusions The risk factors for clinical outcome after IVT in patients with negative SVS may differ from those with positive SVS. ER -