TY - JOUR T1 - Hemodynamic differences between unstable and stable unruptured aneurysms independent of size and location: a pilot study JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 376 LP - 380 DO - 10.1136/neurintsurg-2016-012327 VL - 9 IS - 4 AU - Waleed Brinjikji AU - Bong Jae Chung AU - Carlos Jimenez AU - Christopher Putman AU - David F Kallmes AU - Juan R Cebral Y1 - 2017/04/01 UR - http://jnis.bmj.com/content/9/4/376.abstract N2 - Background While clinical and angiographic risk factors for intracranial aneurysm instability are well established, it is reasonable to postulate that intra-aneurysmal hemodynamics also have a role in aneurysm instability.Objective To identify hemodynamic characteristics that differ between radiologically unstable and stable unruptured intracranial aneurysms.Materials and methods 12 pairs of unruptured intracranial aneurysms with a 3D rotational angiographic set of images and followed up longitudinally without treatment were studied. Each pair consisted of one stable aneurysm (no change on serial imaging) and one unstable aneurysm (demonstrated growth of at least 1 mm diameter or ruptured during follow-up) of matching size (within 10%) and locations. Patient-specific computational fluid dynamics models were created and run under pulsatile flow conditions. Relevant hemodynamic and geometric variables were calculated and compared between groups using the paired Wilcoxon test.Results The area of the aneurysm under low wall shear stress (low shear stress area (LSA)) was 2.26 times larger in unstable aneurysms than in stable aneurysms (p=0.0499). The mean aneurysm vorticity was smaller by a factor of 0.57 in unstable aneurysms compared with stable aneurysms (p=0.0499). No statistically significant differences in geometric variables or shape indices were found.Conclusions This pilot study suggests there may be hemodynamic differences between unstable and stable unruptured cerebral aneurysms. In particular, the area under low wall shear stress was larger in unstable aneurysms. These findings should be considered tentative until confirmed by future larger studies. ER -