@article {Boers431, author = {A M M Boers and O A Berkhemer and C H Slump and W H van Zwam and Y B W E M Roos and A van der Lugt and R J van Oostenbrugge and A J Yoo and D W J Dippel and H A Marquering and C B L M Majoie}, editor = {, and Dippel, DWJ and van der Lugt, A and Majoie, CBLM and Roos, YBWEM and van Oostenbrugge, RJ and van Zwam, WH and Berkhemer, OA and Fransen, PSS and Beumer, D and van den Berg, LA and Schonewille, WJ and Vos, JA and Majoie, CBLM and Roos, YBWEM and Nederkoorn, PJ and Wermer, MJH and van Walderveen, MAA and van Oostenbrugge, RJ and van Zwam, WH and Staals, J and Hofmeijer, J and van Oostayen, JA and Nijeholt, GJ Lycklama {\`a} and Boiten, J and Dippel, DWJ and Brouwer, PA and Emmer, BJ and de Bruijn, SF and van Dijk, LC and JKappelle, L and Lo, RH and van Dijk, EJ and de Vries, J and de Kort, PLM and van den Berg, JSP and van Hasselt, BAAM and Aerden, LAM and Dallinga, RJ and Visser, MC and Bot, JCJ and Vroomen, PC and Eshghi, O and Schreuder, THCML and Heijboer, RJJ and Keizer, K and Tielbeek, AV and den Hertog, HM and Gerrits, DG and van den Berg-Vos, RM and Karas, GB and Marquering, HA and Beenen, LF and Sprengers, MES and Jenniskens, SFM and van den Berg, R and Yoo, AJ and Koudstaal, PJ and Flach, H Zwenneke and Steyerberg, EW and Lingsma, HF and Brown, MM and Liebig, T and Stijnen, T and Andersson, T and Mattle, HP and Wahlgren, N and van der Heijden, Esther and Ghannouti, Naziha and Fleitour, Nadine and Hooijenga, Imke and Lindl-Velema, Annemieke and Puppels, Corina and Pellikaan, Wilma and Janssen, Kirsten and Aaldering, Nicole and Elfrink, Marjan and de Meris, Joke and Geerlings, Annet and van Vemde, Gina and de Ridder, Ans and Greebe, Paut and de Bont-Stikkelbroeck, Jos{\'e} and Struijk, Willy and Simons, Tiny and Messchendorp, Gert and van der Minne, Friedus and Bongenaar, Hester and Bodde, Karin}, title = {Topographic distribution of cerebral infarct probability in patients with acute ischemic stroke: mapping of intra-arterial treatment effect}, volume = {9}, number = {5}, pages = {431--436}, year = {2017}, doi = {10.1136/neurintsurg-2016-012387}, publisher = {British Medical Journal Publishing Group}, abstract = {Background Since proof emerged that IA treatment (IAT) is beneficial for patients with acute ischemic stroke, it has become the standard method of care. Despite these positive results, recovery to functional independence is established in only about one-third of treated patients. The effect of IAT is commonly assessed by functional outcome, whereas its effect on brain tissue salvage is considered a secondary outcome measure (at most). Because patient and treatment selection needs to be improved, understanding the treatment effect on brain tissue salvage is of utmost importance.Objective To introduce infarct probability maps to estimate the location and extent of tissue damage based on patient baseline characteristics and treatment type.Methods Cerebral infarct probability maps were created by combining automatically segmented infarct distributions using follow-up CT images of 281 patients from the MR CLEAN trial. Comparison of infarct probability maps allows visualization and quantification of probable treatment effects. Treatment impact was calculated for 10 Alberta Stroke Program Early CT Score (ASPECTS) and 27 anatomical regions.Results The insular cortex had the highest infarct probability in both control and IAT populations (47.2\% and 42.6\%, respectively). Comparison showed significant lower infarct probability in 4 ASPECTS and 17 anatomical regions in favor of IAT. Most salvaged tissue was found within the ASPECTS M2 region, which was 8.5\% less likely to infarct.Conclusions Probability maps intuitively visualize the topographic distribution of infarct probability due to treatment, which makes it a promising tool for estimating the effect of treatment.}, issn = {1759-8478}, URL = {https://jnis.bmj.com/content/9/5/431}, eprint = {https://jnis.bmj.com/content/9/5/431.full.pdf}, journal = {Journal of NeuroInterventional Surgery} }