PT - JOURNAL ARTICLE AU - Babadjouni, Robin Moshe AU - Radwanski, Ryan E AU - Walcott, Brian P AU - Patel, Arati AU - Durazo, Ramon AU - Hodis, Drew M AU - Emanuel, Benjamin A AU - Mack, William J TI - Neuroprotective strategies following intraparenchymal hemorrhage AID - 10.1136/neurintsurg-2017-013197 DP - 2017 Dec 01 TA - Journal of NeuroInterventional Surgery PG - 1202--1207 VI - 9 IP - 12 4099 - http://jnis.bmj.com/content/9/12/1202.short 4100 - http://jnis.bmj.com/content/9/12/1202.full SO - J NeuroIntervent Surg2017 Dec 01; 9 AB - Intracerebral hemorrhage and, more specifically, intraparenchymal hemorrhage, are devastating disease processes with poor clinical outcomes. Primary injury to the brain results from initial hematoma expansion while secondary hemorrhagic injury occurs from blood-derived products such as hemoglobin, heme, iron, and coagulation factors that overwhelm the brains natural defenses. Novel neuroprotective treatments have emerged that target primary and secondary mechanisms of injury. Nonetheless, translational application of neuroprotectants from preclinical to clinical studies has yet to show beneficial clinical outcomes. This review summarizes therapeutic agents and neuroprotectants in ongoing clinical trials aimed at targeting primary and secondary mechanisms of injury after intraparenchymal hemorrhage.