PT  - JOURNAL ARTICLE
AU  - Pierot, Laurent
AU  - Moret, Jacques
AU  - Barreau, Xavier
AU  - Szikora, Istvan
AU  - Herbreteau, Denis
AU  - Turjman, Francis
AU  - Holtmannspötter, Markus
AU  - Januel, Anne-Christine
AU  - Costalat, Vincent
AU  - Fiehler, Jens
AU  - Klisch, Joachim
AU  - Gauvrit, Jean-Yves
AU  - Weber, Werner
AU  - Desal, Hubert
AU  - Velasco, Stéphane
AU  - Liebig, Thomas
AU  - Stockx, Luc
AU  - Berkefeld, Joachim
AU  - Molyneux, Andrew
AU  - Byrne, James
AU  - Spelle, Laurent
TI  - Safety and efficacy of aneurysm treatment with WEB in the cumulative population of three prospective, multicenter series
AID  - 10.1136/neurintsurg-2017-013448
DP  - 2018 Jun 01
TA  - Journal of NeuroInterventional Surgery
PG  - 553--559
VI  - 10
IP  - 6
4099  - http://jnis.bmj.com/content/10/6/553.short
4100  - http://jnis.bmj.com/content/10/6/553.full
SO  - J NeuroIntervent Surg2018 Jun 01; 10
AB  - Background Flow disruption with the WEB is an innovative endovascular approach for treatment of wide-neck bifurcation aneurysms. Initial studies have shown a low complication rate with good efficacy.Purpose To report clinical and anatomical results of the WEB treatment in the cumulative population of three Good Clinical Practice (GCP) studies: WEBCAST (WEB Clinical Assessment of Intrasaccular Aneurysm), French Observatory, and WEBCAST-2.Methods WEBCAST, French Observatory, and WEBCAST-2 are single-arm, prospective, multicenter, GCP studies dedicated to the evaluation of WEB treatment. Clinical data were independently evaluated. Postoperative and 1-year aneurysm occlusion was independently evaluated using the 3-grade scale: complete occlusion, neck remnant, and aneurysm remnant.Results The cumulative population comprised 168 patients with 169 aneurysms, including 112 female subjects (66.7%). The patients' ages ranged between 27 and 77 years (mean 55.5±10.2 years). Aneurysm locations were middle cerebral artery in 86/169 aneurysms (50.9%), anterior communicating artery in 36/169 (21.3%), basilar artery in 30/169 (17.8%), and internal carotid artery terminus in 17/169 (10.1%). The aneurysm was ruptured in 14/169 (8.3%). There was no mortality at 1 month and procedure/device-related morbidity was 1.2% (2/168). At 1 year, complete aneurysm occlusion was observed in 81/153 aneurysms (52.9%), neck remnant in 40/153 aneurysms (26.1%), and aneurysm remnant in 32/153 aneurysms (20.9%). Re-treatment was carried out in 6.9%.Conclusions This series is at the moment the largest prospective, multicenter, GCP series of patients with aneurysms treated with WEB. It shows the high safety and good mid-term efficacy of this treatment.Clinical trial registration French Observatory: Unique identifier (NCT18069); WEBCAST and WEBCAST-2: Unique identifier (NCT01778322).