RT Journal Article
SR Electronic
T1 Safety and efficacy of aneurysm treatment with WEB in the cumulative population of three prospective, multicenter series
JF Journal of NeuroInterventional Surgery
JO J NeuroIntervent Surg
FD BMJ Publishing Group Ltd.
SP 553
OP 559
DO 10.1136/neurintsurg-2017-013448
VO 10
IS 6
A1 Laurent Pierot
A1 Jacques Moret
A1 Xavier Barreau
A1 Istvan Szikora
A1 Denis Herbreteau
A1 Francis Turjman
A1 Markus Holtmannspötter
A1 Anne-Christine Januel
A1 Vincent Costalat
A1 Jens Fiehler
A1 Joachim Klisch
A1 Jean-Yves Gauvrit
A1 Werner Weber
A1 Hubert Desal
A1 Stéphane Velasco
A1 Thomas Liebig
A1 Luc Stockx
A1 Joachim Berkefeld
A1 Andrew Molyneux
A1 James Byrne
A1 Laurent Spelle
YR 2018
UL http://jnis.bmj.com/content/10/6/553.abstract
AB Background Flow disruption with the WEB is an innovative endovascular approach for treatment of wide-neck bifurcation aneurysms. Initial studies have shown a low complication rate with good efficacy.Purpose To report clinical and anatomical results of the WEB treatment in the cumulative population of three Good Clinical Practice (GCP) studies: WEBCAST (WEB Clinical Assessment of Intrasaccular Aneurysm), French Observatory, and WEBCAST-2.Methods WEBCAST, French Observatory, and WEBCAST-2 are single-arm, prospective, multicenter, GCP studies dedicated to the evaluation of WEB treatment. Clinical data were independently evaluated. Postoperative and 1-year aneurysm occlusion was independently evaluated using the 3-grade scale: complete occlusion, neck remnant, and aneurysm remnant.Results The cumulative population comprised 168 patients with 169 aneurysms, including 112 female subjects (66.7%). The patients' ages ranged between 27 and 77 years (mean 55.5±10.2 years). Aneurysm locations were middle cerebral artery in 86/169 aneurysms (50.9%), anterior communicating artery in 36/169 (21.3%), basilar artery in 30/169 (17.8%), and internal carotid artery terminus in 17/169 (10.1%). The aneurysm was ruptured in 14/169 (8.3%). There was no mortality at 1 month and procedure/device-related morbidity was 1.2% (2/168). At 1 year, complete aneurysm occlusion was observed in 81/153 aneurysms (52.9%), neck remnant in 40/153 aneurysms (26.1%), and aneurysm remnant in 32/153 aneurysms (20.9%). Re-treatment was carried out in 6.9%.Conclusions This series is at the moment the largest prospective, multicenter, GCP series of patients with aneurysms treated with WEB. It shows the high safety and good mid-term efficacy of this treatment.Clinical trial registration French Observatory: Unique identifier (NCT18069); WEBCAST and WEBCAST-2: Unique identifier (NCT01778322).