RT Journal Article
SR Electronic
T1 Safety and efficacy of aneurysm treatment with WEB in the cumulative population of three prospective, multicenter series
JF Journal of NeuroInterventional Surgery
JO J NeuroIntervent Surg
FD BMJ Publishing Group Ltd.
SP 553
OP 559
DO 10.1136/neurintsurg-2017-013448
VO 10
IS 6
A1 Pierot, Laurent
A1 Moret, Jacques
A1 Barreau, Xavier
A1 Szikora, Istvan
A1 Herbreteau, Denis
A1 Turjman, Francis
A1 Holtmannspötter, Markus
A1 Januel, Anne-Christine
A1 Costalat, Vincent
A1 Fiehler, Jens
A1 Klisch, Joachim
A1 Gauvrit, Jean-Yves
A1 Weber, Werner
A1 Desal, Hubert
A1 Velasco, Stéphane
A1 Liebig, Thomas
A1 Stockx, Luc
A1 Berkefeld, Joachim
A1 Molyneux, Andrew
A1 Byrne, James
A1 Spelle, Laurent
YR 2018
UL http://jnis.bmj.com/content/10/6/553.abstract
AB Background Flow disruption with the WEB is an innovative endovascular approach for treatment of wide-neck bifurcation aneurysms. Initial studies have shown a low complication rate with good efficacy.Purpose To report clinical and anatomical results of the WEB treatment in the cumulative population of three Good Clinical Practice (GCP) studies: WEBCAST (WEB Clinical Assessment of Intrasaccular Aneurysm), French Observatory, and WEBCAST-2.Methods WEBCAST, French Observatory, and WEBCAST-2 are single-arm, prospective, multicenter, GCP studies dedicated to the evaluation of WEB treatment. Clinical data were independently evaluated. Postoperative and 1-year aneurysm occlusion was independently evaluated using the 3-grade scale: complete occlusion, neck remnant, and aneurysm remnant.Results The cumulative population comprised 168 patients with 169 aneurysms, including 112 female subjects (66.7%). The patients' ages ranged between 27 and 77 years (mean 55.5±10.2 years). Aneurysm locations were middle cerebral artery in 86/169 aneurysms (50.9%), anterior communicating artery in 36/169 (21.3%), basilar artery in 30/169 (17.8%), and internal carotid artery terminus in 17/169 (10.1%). The aneurysm was ruptured in 14/169 (8.3%). There was no mortality at 1 month and procedure/device-related morbidity was 1.2% (2/168). At 1 year, complete aneurysm occlusion was observed in 81/153 aneurysms (52.9%), neck remnant in 40/153 aneurysms (26.1%), and aneurysm remnant in 32/153 aneurysms (20.9%). Re-treatment was carried out in 6.9%.Conclusions This series is at the moment the largest prospective, multicenter, GCP series of patients with aneurysms treated with WEB. It shows the high safety and good mid-term efficacy of this treatment.Clinical trial registration French Observatory: Unique identifier (NCT18069); WEBCAST and WEBCAST-2: Unique identifier (NCT01778322).