TY - JOUR T1 - Mechanical thrombectomy in orally anticoagulated patients with acute ischemic stroke JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 834 LP - 838 DO - 10.1136/neurintsurg-2017-013504 VL - 10 IS - 9 AU - Gustavo Zapata-Wainberg AU - Álvaro Ximénez-Carrillo AU - Santiago Trillo AU - Blanca Fuentes AU - Antonio Cruz-Culebras AU - Clara Aguirre AU - María Alonso de Leciñana AU - Rocío Vera AU - Eduardo Bárcena AU - Andrés Fernández-Prieto AU - José Carlos Méndez-Cendón AU - Jose Luis Caniego AU - Exuperio Díez-Tejedor AU - Jaime Masjuan AU - José Vivancos A2 - , Y1 - 2018/09/01 UR - http://jnis.bmj.com/content/10/9/834.abstract N2 - Background and purpose To investigate the efficacy and safety of mechanical thrombectomy in patients with acute ischemic stroke according to the oral anticoagulation medication taken at the time of stroke onset.Materials and methods A retrospective multicenter study of prospectively collected data based on data from the registry the Madrid Stroke Network was performed. We included consecutive patients with acute ischemic stroke treated with mechanical thrombectomy and compared the frequency of intracranial hemorrhage and the modified Rankin Scale (mRS) score at 3 months according to anticoagulation status.Results The study population comprised 502 patients, of whom 389 (77.5%) were not anticoagulated, 104 (20.7%) were taking vitamin K antagonists, and 9 (1.8%) were taking direct oral anticoagulants. Intravenous thrombolysis had been performed in 59.8% and 15.0% of non-anticoagulated and anticoagulated patients, respectively. Rates of intracranial hemorrhage after treatment were similar between non-anticoagulated and anticoagulated patients, as were rates of recanalization. After 3 months of follow-up, the mRS score was ≤2 in 56.3% and 55.7% of non-anticoagulated and anticoagulated patients, respectively (P=NS). Mortality rates were similar in the two groups (13.1%and12.4%, respectively). Among anticoagulated patients, no differences were found for intracranial bleeding, mRS score, or mortality rates between patients taking vitamin K antagonists and those taking direct oral anticoagulants.Conclusions Mechanical thrombectomy is feasible in anticoagulated patients with acute ischemic stroke. The outcomes and safety profile are similar to those of patients with no prior anticoagulation therapy. ER -