RT Journal Article SR Electronic T1 Association of follow-up infarct volume with functional outcome in acute ischemic stroke: a pooled analysis of seven randomized trials JF Journal of NeuroInterventional Surgery JO J NeuroIntervent Surg FD BMJ Publishing Group Ltd. SP 1137 OP 1142 DO 10.1136/neurintsurg-2017-013724 VO 10 IS 12 A1 Boers, Anna M M A1 Jansen, Ivo G H A1 Beenen, Ludo F M A1 Devlin, Thomas G A1 San Roman, Luis A1 Heo, Ji Hoe A1 Ribó, Marc A1 Brown, Scott A1 Almekhlafi, Mohammed A A1 Liebeskind, David S A1 Teitelbaum, Jeanne A1 Lingsma, Hester F A1 van Zwam, Wim H A1 Cuadras, Patricia A1 du Mesnil de Rochemont, Richard A1 Beaumont, Marine A1 Brown, Martin M A1 Yoo, Albert J A1 van Oostenbrugge, Robert J A1 Menon, Bijoy K A1 Donnan, Geoffrey A A1 Mas, Jean Louis A1 Roos, Yvo B W E M A1 Oppenheim, Catherine A1 van der Lugt, Aad A1 Dowling, Richard J A1 Hill, Michael D A1 Davalos, Antoni A1 Moulin, Thierry A1 Agrinier, Nelly A1 Demchuk, Andrew M A1 Lopes, Demetrius K A1 Aja Rodríguez, Lucia A1 Dippel, Diederik W J A1 Campbell, Bruce C V A1 Mitchell, Peter J A1 Al-Ajlan, Fahad S A1 Jovin, Tudor G A1 Madigan, Jeremy A1 Albers, Gregory W A1 Soize, Sebastien A1 Guillemin, Francis A1 Reddy, Vivek K A1 Bracard, Serge A1 Blasco, Jordi A1 Muir, Keith W A1 Nogueira, Raul G A1 White, Phil M A1 Goyal, Mayank A1 Davis, Stephen M A1 Marquering, Henk A A1 Majoie, Charles B L M YR 2018 UL http://jnis.bmj.com/content/10/12/1137.abstract AB Background Follow-up infarct volume (FIV) has been recommended as an early indicator of treatment efficacy in patients with acute ischemic stroke. Questions remain about the optimal imaging approach for FIV measurement.Objective To examine the association of FIV with 90-day modified Rankin Scale (mRS) score and investigate its dependency on acquisition time and modality.Methods Data of seven trials were pooled. FIV was assessed on follow-up (12 hours to 2 weeks) CT or MRI. Infarct location was defined as laterality and involvement of the Alberta Stroke Program Early CT Score regions. Relative quality and strength of multivariable regression models of the association between FIV and functional outcome were assessed. Dependency of imaging modality and acquisition time (≤48 hours vs >48 hours) was evaluated.Results Of 1665 included patients, 83% were imaged with CT. Median FIV was 41 mL (IQR 14–120). A large FIV was associated with worse functional outcome (OR=0.88(95% CI 0.87 to 0.89) per 10 mL) in adjusted analysis. A model including FIV, location, and hemorrhage type best predicted mRS score. FIV of ≥133 mL was highly specific for unfavorable outcome. FIV was equally strongly associated with mRS score for assessment on CT and MRI, even though large differences in volume were present (48 mL (IQR 15–131) vs 22 mL (IQR 8–71), respectively). Associations of both early and late FIV assessments with outcome were similar in strength (ρ=0.60(95% CI 0.56 to 0.64) and ρ=0.55(95% CI 0.50 to 0.60), respectively).Conclusions In patients with an acute ischemic stroke due to a proximal intracranial occlusion of the anterior circulation, FIV is a strong independent predictor of functional outcome and can be assessed before 48 hours, oneither CT or MRI.