PT  - JOURNAL ARTICLE
AU  - Yongtao Guo
AU  - Wenjie Zi
AU  - Yue Wan
AU  - Shuai Zhang
AU  - Bo Sun
AU  - Xianjin Shang
AU  - Shun Li
AU  - Yongjie Bai
AU  - Zibao Li
AU  - Dequan Zheng
AU  - Xinfeng Liu
TI  - Leukoaraiosis severity and outcomes after mechanical thrombectomy with stent-retriever devices in acute ischemic stroke
AID  - 10.1136/neurintsurg-2018-014018
DP  - 2019 Feb 01
TA  - Journal of NeuroInterventional Surgery
PG  - 137--140
VI  - 11
IP  - 2
4099  - http://jnis.bmj.com/content/11/2/137.short
4100  - http://jnis.bmj.com/content/11/2/137.full
SO  - J NeuroIntervent Surg2019 Feb 01; 11
AB  - Background and purpose The aim of the study was to evaluate whether leukoaraiosis severity is associated with outcome in acute stroke patients undergoing mechanical thrombectomy with stent-retriever devices.Methods In this retrospective multicenter study, we evaluated 251 acute stroke patients (pretreatment National Institutes of Health Stroke Scale score ≥8) treated with stent-retriever devices. Leukoaraiosis severity was graded as 0–2 (absent-to-moderate) versus 3–4 (severe) according to the van Swieten scale. The main clinical outcome was the proportion of good functional outcome, defined as a modified Rankin Scale of 0–2 at 90 days.Results Significantly fewer patients in the severe LA group than in the absent-to-moderate LA group achieved a good functional outcome (18.4% vs 50.2%, P<0.001). In multivariable analysis, severe leukoaraiosis was a significant negative predictor of good functional outcome at 90 days (OR, 0.27; 95% CI 0.10–0.77; P=0.014).Conclusions The severity of leukoaraiosis is independently associated with 90-day functional outcome in acute stroke patients undergoing mechanical thrombectomy with stent-retriever devices.