TY - JOUR T1 - Vascular wall components in thrombi obtained by acute stroke thrombectomy: clinical significance and related factors JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 232 LP - 236 DO - 10.1136/neurintsurg-2018-014041 VL - 11 IS - 3 AU - Naoko Funatsu AU - Mikito Hayakawa AU - Tetsuya Hashimoto AU - Hiroshi Yamagami AU - Tetsu Satow AU - Jun C Takahashi AU - Masatoshi Koga AU - Kazuyuki Nagatsuka AU - Hatsue Ishibashi-Ueda AU - Toru Iwama AU - Kazunori Toyoda Y1 - 2019/03/01 UR - http://jnis.bmj.com/content/11/3/232.abstract N2 - Background and purpose Vascular wall components (VWCs) are sometimes identified as collagen fibers in specimens retrieved by thrombectomy from acute stroke patients. However, their clinical significance and associated factors remain unclear. The purpose of this study was to clarify the factors associated with VWCs in retrieved thrombi.Methods Consecutive acute stroke patients treated endovascularly using the Penumbra aspiration catheter or stent retrievers (SRs) at our institute from November 2013 to April 2016 were retrospectively reviewed, and the retrieved thrombi were evaluated histopathologically. VWCs were defined as banded collagen fibers with a distinct boundary observed at the rim or outside of the retrieved thrombi. Factors associated with the presence of VWCs were studied.Results A total of 150 specimens (76 specimens retrieved by the Penumbra, 74 by SRs) from 101 patients (47 women, age 74.9±11.1 years) were investigated. Applied thrombectomy devices were aspiration catheters in 42 patients, SRs in 21 patients, and both in 38 patients. VWCs were observed in 24 specimens (16%) from 22 patients. A low proportion of erythrocyte components (41.7±24.8% vs 55.0±26.3%, P=0.01), a high frequency of the devices reaching the M2/P2 (75% vs 50%, P=0.02), and a high number of device passages (P for trend=0.02) were associated with VWC positive thrombi. Successful recanalization (Treatment in Cerebral Ischemia ≥2b) tended to be less frequent in patients with VWC positive thrombi than in those without (73% vs 89%, P=0.06).Conclusions The histopathology of occlusive thrombi, arterial sites where devices reached, and number of device passages, might affect the presence of VWCs in retrieved thrombi. ER -