TY - JOUR T1 - Prevalence of large vessel occlusion in patients presenting with acute ischemic stroke: a 10-year systematic review of the literature JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 241 LP - 245 DO - 10.1136/neurintsurg-2018-014239 VL - 11 IS - 3 AU - Nikita Lakomkin AU - Mandip Dhamoon AU - Kirsten Carroll AU - Inder Paul Singh AU - Stanley Tuhrim AU - Joyce Lee AU - Johanna T Fifi AU - J Mocco Y1 - 2019/03/01 UR - http://jnis.bmj.com/content/11/3/241.abstract N2 - Background Accurate assessment of the prevalence of large vessel occlusion (LVO) in patients presenting with acute ischemic stroke (AIS) is critical for optimal resource allocation in neurovascular intervention.Objective To perform a systematic review of the literature in order to identify the proportion of patients with AIS presenting with LVO on image analysis.Methods A systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in order to identify studies reporting LVO rates for patients presenting with AIS. Studies that included patients younger than 18 years, were non-clinical, or did not report LVO rates in the context of a consecutive AIS series were excluded. Characteristics regarding presentation, diagnosis, and LVO classification were recorded for each paper.Results Sixteen studies, spanning a total of 11 763 patients assessed for stroke, were included in the qualitative synthesis. The majority (10/16) of articles reported LVO rates exceeding 30% in patients presenting with AIS. There was substantial variability in the LVO definitions used, with nine unique classification schemes among the 16 studies. The mean prevalence of LVO was 31.1% across all studies, and 29.3% when weighted by the number of patients included in each study.Conclusions Despite the wide variability in LVO classification, the majority of studies in the last 10 years report a high prevalence of LVO in patients presenting with AIS. These rates of LVO may have implications for the volume of patients with AIS who may benefit from endovascular therapy. ER -