PT  - JOURNAL ARTICLE
AU  - Michal Zawadzki
AU  - Jerzy Walecki
AU  - Boguslaw Kostkiewicz
AU  - Kacper Kostyra
AU  - Monica Smith Pearl
AU  - Meiyappan Solaiyappan
AU  - Piotr Walczak
AU  - Miroslaw Janowski
TI  - Republished: Real-time MRI guidance for intra-arterial drug delivery in a patient with a brain tumor: technical note
AID  - 10.1136/neurintsurg-2018-014469.rep
DP  - 2019 Aug 01
TA  - Journal of NeuroInterventional Surgery
PG  - e3--e3
VI  - 11
IP  - 8
4099  - http://jnis.bmj.com/content/11/8/e3.short
4100  - http://jnis.bmj.com/content/11/8/e3.full
SO  - J NeuroIntervent Surg2019 Aug 01; 11
AB  - Patients suffering from malignant brain tumors are burdened with a grim prognosis. The blood brain barrier is considered a primary obstacle in therapeutic drug delivery to the brain. Intra-arterial (IA) delivery of therapeutic agents following osmotic BBB opening has been attempted for years, but high variability has limited its widespread implementation. It has been recently shown in animal studies that MRI is superior to X-ray for guiding IA infusions, as it allows direct visualization of the brain parenchyma perfused and facilitates predictable drug targeting. Moreover, PET imaging has revealed that IA, not intravenous, delivery of bevacizumab results in brain accumulation, providing strong rationale for utilizing the IA route. Here, we present our experience in a patient with recurrent butterfly glioblastoma enrolled in first-in-man MRI-guided neurointervention for targeted IA drug delivery.