PT - JOURNAL ARTICLE AU - Meinel, Thomas Raphael AU - Kaesmacher, Johannes AU - Chaloulos-Iakovidis, Panagiotis AU - Panos, Leonidas AU - Mordasini, Pasquale AU - Mosimann, Pascal J AU - Michel, Patrik AU - Hajdu, Steven AU - Ribo, Marc AU - Requena, Manuel AU - Maegerlein, Christian AU - Friedrich, Benjamin AU - Costalat, Vincent AU - Benali, Amel AU - Pierot, Laurent AU - Gawlitza, Matthias AU - Schaafsma, Joanna AU - Pereira, Vitor M AU - Gralla, Jan AU - Fischer, Urs TI - Mechanical thrombectomy for basilar artery occlusion: efficacy, outcomes, and futile recanalization in comparison with the anterior circulation AID - 10.1136/neurintsurg-2018-014516 DP - 2019 Dec 01 TA - Journal of NeuroInterventional Surgery PG - 1174--1180 VI - 11 IP - 12 4099 - http://jnis.bmj.com/content/11/12/1174.short 4100 - http://jnis.bmj.com/content/11/12/1174.full SO - J NeuroIntervent Surg2019 Dec 01; 11 AB - Background Performing mechanical thrombectomy (MT) in patients with basilar artery occlusion (BAO) is currently not evidence-based.Objective To compare patients’ outcome, relative merits of achieving recanalization, and predictors of futile recanalization (FR) between BAO and anterior circulation large vessel occlusion (ACLVO) MT.Methods In the multicenter BEYOND-SWIFT registry (NCT03496064), univariate and multivariate (displayed as adjusted Odds Ratios, aOR and 95% confidence intervals, 95%-CI) outcome comparisons between BAO (N=165) and ACLVO (N=1574) were performed. The primary outcome was favorable outcome at 90 days (modified Rankin Scale, mRS 0-2). Secondary outcome included mortality, symptomatic intracranial hemorrhage (sICH) and FR. The relative merits of achieving successful recanalization between ACLVO and BAO were evaluated with interaction terms.Results MT in BAO was more often technically effective and equally safe in regards to mortality and sICH when compared to ACLVO. When adjusting for baseline differences, there was no significant difference between BAO vs ACLVO regarding rates of favorable outcome (aOR 0.986, 95%-CI 0.553 – 1.758). However, BAO were associated with increased rates of FR (aOR 2.146, 95%-CI 1.267 – 3.633). Predictors for FR were age, stroke severity, maneuver count and intracranial stenting. No significant heterogeneity on the relative merits of achieving successful recanalization on several outcome parameters were observed when comparing BAO and ACLVO.Conclusions In selected patients, similar outcomes can be achieved in BAO and ACLVO patients treated with MT. Randomized controlled trials comparing patient selection and interventional strategies seem warranted to avoid FR.Trial registration number NCT03496064