PT  - JOURNAL ARTICLE
AU  - Ana Paula Narata
AU  - Fernando Moura
AU  - Ignacio Larrabide
AU  - René Chapot
AU  - Christophe Cognard
AU  - Anne-Christine Januel
AU  - Stéphane Velasco
AU  - Ayache Bouakaz
AU  - Frederic Patat
AU  - Alberto Marzo
TI  - Role of distal cerebral vasculature in vessel constriction after aneurysm treatment with flow diverter stents
AID  - 10.1136/neurintsurg-2019-015447
DP  - 2020 Aug 01
TA  - Journal of NeuroInterventional Surgery
PG  - 818--826
VI  - 12
IP  - 8
4099  - http://jnis.bmj.com/content/12/8/818.short
4100  - http://jnis.bmj.com/content/12/8/818.full
SO  - J NeuroIntervent Surg2020 Aug 01; 12
AB  - Background Treatment of intracranial aneurysms with flow diverter stent (FDS) procedures can lead to caliber changes of jailed vessels. The reason some branches remain unchanged and others are affected by narrowing remains unknown.Objective To investigate the influence of resistance to flow from distal vasculature on stent-induced hemodynamic modifications affecting bifurcating vessels.Materials and methods Radiological images and demographic data were acquired for 142 aneurysms treated with a FDS. Vascular resistance was estimated from patient-specific anatomic data. Correlation analysis was used to identify correspondence between anatomic data and clinical outcome. Computational Fluid Dynamics was performed on a typical patient-specific model to evaluate the influence of FDS on flow. Relevant hemodynamic variables along the bifurcating vessels were quantitatively analyzed and validated with in vitro data obtained using power Doppler ultrasound.Results Statistical analysis showed a correlation between clinical outcome and FDS resistance to flow considering overall jailed vessel vascular resistance (r=0.5, P<0.001). Computational predictions of blood flow showed that hemodynamics is minimally affected by FDS treatment in the ophthalmic artery.Conclusions Jailed vessels are affected by narrowing when resistance to flow from the FDS constitutes a larger proportion of the overall vessel resistance to flow. This knowledge may contribute to better understanding of intracranial hemodynamics after a FDS procedure and reinforce indications for flow diversion in the treatment of intracranial aneurysms.