RT Journal Article
SR Electronic
T1 Ophthalmic artery catheterization for retinoblastoma treatment: does reflux affect tumor response?
JF Journal of NeuroInterventional Surgery
JO J NeuroIntervent Surg
FD BMJ Publishing Group Ltd.
SP 915
OP 920
DO 10.1136/neurintsurg-2019-015597
VO 12
IS 9
A1 Ahmad Sweid
A1 Batoul Hammoud
A1 Joshua H Weinberg
A1 Pavlos Texakalidis
A1 Vivian Xu
A1 Kavya Shivashankar
A1 Michael P Baldassari
A1 Somnath Das
A1 Stavropoula I Tjoumakaris
A1 Carol L Shields
A1 David A Lezama
A1 Li-Anne S Lim
A1 Lauren A Dalvin
A1 Kareem El Naamani
A1 Pascal Jabbour
YR 2020
UL http://jnis.bmj.com/content/12/9/915.abstract
AB Background Intra-arterial chemotherapy (IAC) for retinoblastoma (Rb) has been established as a primary treatment for the disease. To determine whether the presence of reflux into the ICA is associated with tumor response or with any other adverse events in pediatric retinoblastoma patients.Methods A retrospective chart review was performed for patients diagnosed with Rb and managed with ophthalmic artery catheterization (OAC).Results The total study cohort included 205 Rb tumors of 205 eyes in 194 consecutive patients who underwent 624 successful intra-arterial chemotherapy infusions using OAC. Of the 205 eyes, 65 eyes (32.7%) underwent 157 OAC procedures constituted group A (no reflux), 64 eyes (31.2%) underwent 236 OAC procedures constituted group B (variable pattern), and 74 eyes (36.1%) underwent 231 OAC procedures constituted group C (reflux). There was no significant difference in baseline characteristics between the three cohorts. Also, there was no significant difference in tumor characteristics between the three groups, except for genetic status. There was no significant difference between the three groups in terms of tumor response at completion of the treatment regimen. Complete tumor response was achieved at 70.2% in Group A, at 83.3% in Group B, and at 78.5% in group C (P=0.39). Similarly, eye enucleation occurred at 38.5% in group A, 31.8% in group B, and 31.5% in group C. None of the patients in both groups had any neurological adverse events or new onset of seizures.Conclusions The presence of reflux, which may complicate the procedure and prolong it, was not associated with poor outcomes in our analysis.