PT  - JOURNAL ARTICLE
AU  - Antonius Mattheus de Korte
AU  - René Aquarius
AU  - Thomas Vogl
AU  - Johannes Roth
AU  - Ronald H M A Bartels
AU  - Hieronymus D Boogaarts
AU  - Peter L E M van Lent
AU  - Joost De Vries
TI  - Elevation of inflammatory S100A8/S100A9 complexes in intracranial aneurysms
AID  - 10.1136/neurintsurg-2019-015753
DP  - 2020 Nov 01
TA  - Journal of NeuroInterventional Surgery
PG  - 1117--1121
VI  - 12
IP  - 11
4099  - http://jnis.bmj.com/content/12/11/1117.short
4100  - http://jnis.bmj.com/content/12/11/1117.full
SO  - J NeuroIntervent Surg2020 Nov 01; 12
AB  - Background Inflammation-related factors might give further insight into the pathophysiology of vessel wall inflammation and intracranial aneurysm (IA) rupture. One of these factors is the protein complex S100A8/A9, which is released by neutrophils, monocytes, and activated macrophages and is known for its role in cardiovascular disease.Objective To determine if venous S100A8/A9 levels in patients with a ruptured IA (rIA) or unruptured IA (uIA) are elevated compared with a control group. Second, to assess differences between venous and intra-aneurysmal S100A8/A9 levels of rIA and uIA patients.Methods A prospective case study was performed between June 2016 and May 2017 in patients harboring a ruptured or unruptured saccular IA. Primary outcome measures were individual S100A8/A9 serum concentrations as measured in venous and intra-aneurysmal blood samples during endovascular treatment. Venous serum S100A8/A9 concentrations from a healthy control group served as a reference.Results We included 16 patients with either a rIA or uIA and 47 healthy controls. Venous S100A8/A9 concentrations were higher in aneurysm patients (rIA and uIA) than those of healthy controls (P≤0.001). S100A8/A9 concentrations were higher in intra-aneurysmal samples than in venous samples of rIA patients (P=0.011). This difference was not found in uIA patients (P=0.054). Intra-aneurysmal S100A8/A9 levels were higher in rIAs than in uIAs (P=0.04).Conclusions Venous S100A8/A9 levels are elevated in patients with both rIAs and uIAs compared with healthy controls and likely represents aneurysm wall inflammation. S100A8/A9 causes macrophage-induced inflammation and degeneration of the vessel wall which might explain higher intra-aneurysmal S100A8/A9 levels found in rIAs than in uIAs.