PT  - JOURNAL ARTICLE
AU  - Amanda Zakeri
AU  - Ashutosh P Jadhav
AU  - Bruce A Sullenger
AU  - Shahid M Nimjee
TI  - Ischemic stroke in COVID-19-positive patients: an overview of SARS-CoV-2 and thrombotic mechanisms for the neurointerventionalist
AID  - 10.1136/neurintsurg-2020-016794
DP  - 2021 Mar 01
TA  - Journal of NeuroInterventional Surgery
PG  - 202--206
VI  - 13
IP  - 3
4099  - http://jnis.bmj.com/content/13/3/202.short
4100  - http://jnis.bmj.com/content/13/3/202.full
SO  - J NeuroIntervent Surg2021 Mar 01; 13
AB  - Coronavirus disease 2019 (COVID-19) results from infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first reported in Wuhan, China in patients suffering from severe pneumonia and acute respiratory distress syndrome and has now grown into the first pandemic in over 100 years. Patients infected with SARS-CoV-2 develop arterial thrombosis including stroke, myocardial infarction and peripheral arterial thrombosis, all of which result in poor outcomes despite maximal medical, endovascular, and microsurgical treatment compared with non-COVID-19-infected patients. In this review we provide a brief overview of SARS-CoV-2, the infectious agent responsible for the COVID-19 pandemic, and describe the mechanisms responsible for COVID-19-associated coagulopathy. Finally, we discuss the impact of COVID-19 on ischemic stroke, focusing on large vessel occlusion.