TY - JOUR T1 - The importance of wall degeneration in preclinical aneurysm models JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 200 LP - 201 DO - 10.1136/neurintsurg-2020-016926 VL - 13 IS - 3 AU - Basil Erwin Grüter AU - Serge Marbacher Y1 - 2021/03/01 UR - http://jnis.bmj.com/content/13/3/200.abstract N2 - Recently, King et al reported having successfully established an extracranial aneurysm model in rabbits that reflects wall degeneration, capacity of growth and potential rupture.1 These are fundamental biological characteristics of human intracranial aneurysms (IAs). Developing an appropriate animal model is of utmost importance for the study of clinical conditions in a preclinical setting. To date, however, only a small minority of the many previously proposed preclinical extracranial aneurysm models2 3 have included decellularized and degenerated walls.Unlike microsurgical clipping, which causes immediate mechanical occlusion, aneurysm healing after endovascular treatments depends on a biological response.4 Coil materials are used to induce a thrombus in the aneurysm sac and immediately exclude the aneurysm from blood circulation. Long-term healing, however, relies on thrombus remodelling. A large number of cells are required to organize the early thrombus into mature scar tissue and eventually form a neointima.5 6 These cells are predominantly recruited from the aneurysm wall and the … ER -