TY - JOUR T1 - Nuisance bleeding complications in patients with cerebral aneurysm treated with Pipeline embolization device JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 247 LP - 250 DO - 10.1136/neurintsurg-2020-016245 VL - 13 IS - 3 AU - Elliot Pressman AU - Carlos A De la Garza AU - Felix Chin AU - Jacob Fishbein AU - Muhammad Waqas AU - Adnan Siddiqui AU - Kenneth Snyder AU - Jason M Davies AU - Elad Levy AU - Peter Kan AU - Zeguang Ren AU - Maxim Mokin Y1 - 2021/03/01 UR - http://jnis.bmj.com/content/13/3/247.abstract N2 - Background Patients with cerebral aneurysms treated with the Pipeline embolization device (PED) are maintained on dual antiplatelet therapy (DAPT) to prevent thromboembolic complications. Rates of minor, “nuisance” bleeding in these patients remain unknown. We sought to evaluate the frequency and factors associated with this bleeding and its effect on DAPT compliance.Methods We performed a multicenter retrospective cohort study on consecutive cases of intracranial aneurysms treated with PED. Patient characteristics, aneurysm characteristics, and bleeding complications were analyzed. Severity of bleeding was defined according to a previously published classification defining nuisance bleeding as easy bruising, bleeding from small cuts, petechia, and ecchymosis.Results 245 PED aneurysm procedures on 243 patients were retrospectively collected from three academic centers over a 4.25-year period. Sixty-seven patients (27%) had nuisance bleeds. Patients with a higher risk of nuisance bleeding were older (59.1±3.4 vs . 54.7±2.2, P=0.032). Patients with nuisance bleeds were more likely to have their DAPT regimen changed or dose lowered (29% vs 8.3%, P<0.001), were on DAPT for less time (10.0 months±2.60 vs. 14.6 months±1.95, P=0.005) and were more likely to have aneurysm occlusion at 6 months (P<0.001). Stepwise logistic regression found age predictive of a nuisance bleed (OR=1.033)Conclusions Nuisance bleeding was a common complaint of PED-treated aneurysm patients maintained on DAPT. Increasing age and aneurysmal occlusion at 6 months were the only factors predictive of nuisance bleeds. Clinicians were more likely to adjust antiplatelet regimens or stop DAPT early given a nuisance bleed. ER -