TY - JOUR T1 - Delayed thromboembolic events after coiling of unruptured intracranial aneurysms in a prospective cohort of 335 patients JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 534 LP - 540 DO - 10.1136/neurintsurg-2020-016654 VL - 13 IS - 6 AU - Laurent Pierot AU - Coralie Barbe AU - Denis Herbreteau AU - Jean-Yves Gauvrit AU - Anne-Christine Januel AU - Fouzi Bala AU - Frédéric Ricolfi AU - Hubert Desal AU - Stéphane Velasco AU - Mohamed Aggour AU - Emmanuel Chabert AU - Jacques Sedat AU - Denis Trystram AU - Gaultier Marnat AU - Sophie Gallas AU - Georges Rodesch AU - Frédéric Clarençon AU - Chrysanthi Papagiannaki AU - Phil White AU - Laurent Spelle Y1 - 2021/06/01 UR - http://jnis.bmj.com/content/13/6/534.abstract N2 - Background Coiling is the first-line treatment for the management of unruptured intracranial aneurysms (UIAs), but delayed thromboembolic events (TEEs) can occur after such treatment. ARETA (Analysis of Recanalization after Endovascular Treatment of Intracranial Aneurysm) is a prospective multicenter study conducted to analyze aneurysm recanalization. We analyzed delayed TEEs in the UIA subgroup.Methods Sixteen neurointerventional departments prospectively enrolled patients treated for ruptured and unruptured aneurysms between December 2013 and May 2015. Participant demographics, aneurysm characteristics, and endovascular techniques were recorded. Data were analyzed from participants with UIA treated by coiling or balloon-assisted coiling. We assessed the rates, timing, management, clinical outcomes, and risk factors for delayed TEEs using univariable and multivariable analyses.Results The rate of delayed TEEs was 2.4% (95% CI 1.0% to 4.6%) in patients with unruptured aneurysms, with all events occurring in the week following the procedure. In multivariate analysis, two factors were associated with delayed TEEs: autosomal dominant polycystic kidney disease (ADPKD): 20.0% in patients with ADPKD vs 1.9% in patients without ADPKD (OR 27.3 (95% CI 3.9 to 190.2), p=0.0008) and post-procedure aneurysm remnant: 9.4% in patients with post-procedure aneurysm remnant vs 1.6% in patients with adequate occlusion (OR 9.9 (95% CI 1.0 to 51.3), p=0.006). We describe modalities of management as well as clinical outcomes.Conclusions Delayed TEE is a relatively rare complication after coiling of UIAs. In this series, all occurred in the week following the initial procedure. Two factors were associated with delayed TEE: ADPKD and aneurysm remnant at procedure completion.Clinical trial registration NCT01942512 Data are available upon reasonable request by contacting the corresponding author. ER -