TY - JOUR T1 - Risk of intracranial hemorrhage associated with pregnancy in women with cerebral arteriovenous malformations JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 707 LP - 710 DO - 10.1136/neurintsurg-2020-016838 VL - 13 IS - 8 AU - Songmi Lee AU - Youngran Kim AU - Babak B Navi AU - Rania Abdelkhaleq AU - Sergio Salazar-Marioni AU - Spiros L Blackburn AU - Arvind B Bambhroliya AU - Victor Lopez-Rivera AU - Farhaan Vahidy AU - Sean I Savitz AU - Annika Medhus AU - Hooman Kamel AU - James C Grotta AU - Louise McCullough AU - Peng Roc Chen AU - Sunil A Sheth Y1 - 2021/08/01 UR - http://jnis.bmj.com/content/13/8/707.abstract N2 - Background Prior studies on rupture risk of brain arteriovenous malformations (AVMs) in women undergoing pregnancy and delivery have reported conflicting findings, but also have not accounted for AVM morphology and heterogeneity. Here, we assess the association between pregnancy and the risk of intracranial hemorrhage (ICH) in women with AVMs using a cohort-crossover design in which each woman serves as her own control.Methods Women who underwent pregnancy and delivery were identified using DRG codes from the Healthcare Cost and Utilization Project State Inpatient Databases for California (2005–2011), Florida (2005–2014), and New York (2005–2014). The presence of AVM and ICH was determined using ICD 9 codes. Pregnancy was defined as the 40 weeks prior to delivery, and postpartum as 12 weeks after. We defined a non-exposure control period as a 52-week period prior to pregnancy. The relative risks of ICH during pregnancy were compared against the non-exposure period using conditional Poisson regression.Results Among 4 022 811 women identified with an eligible delivery hospitalization (median age, 28 years; 7.3% with gestational diabetes; 4.5% with preeclampsia/eclampsia), 568 (0.014%) had an AVM. The rates of ICH during pregnancy and puerperium were 6355.4 (95% CI 4279.4 to 8431.5) and 14.4 (95% CI 13.3 to 15.6) per 100 000 person-years for women with and without AVM, respectively. In cohort-crossover analysis, in women with AVMs the risk of ICH increased 3.27-fold (RR, 95% CI 1.67 to 6.43) during pregnancy and puerperium compared with a non-pregnant period.Conclusions Among women with AVM, pregnancy and puerperium were associated with a greater than 3-fold risk of ICH.Data are available in a public, open access repository. Data are publicly available at the Healthcare Cost and Utilization Project (HCUP) website. ER -