PT  - JOURNAL ARTICLE
AU  - Tengfei Zhou
AU  - Tingyu Yi
AU  - Tianxiao Li
AU  - Liangfu Zhu
AU  - Yucheng Li
AU  - Zhaoshuo Li
AU  - Meiyun Wang
AU  - Qiang Li
AU  - Yingkun He
AU  - Pengfei Yang
AU  - Yongwei Zhang
AU  - Zifu Li
AU  - Yongxin Zhang
AU  - Xiaofei Ye
AU  - Wenhuo Chen
AU  - Shouchun Wang
AU  - Jianmin Liu
ED  - ,
TI  - Predictors of futile recanalization in patients undergoing endovascular treatment in the DIRECT-MT trial
AID  - 10.1136/neurintsurg-2021-017765
DP  - 2021 Sep 02
TA  - Journal of NeuroInterventional Surgery
PG  - neurintsurg-2021-017765
4099  - http://jnis.bmj.com/content/early/2021/09/02/neurintsurg-2021-017765.short
4100  - http://jnis.bmj.com/content/early/2021/09/02/neurintsurg-2021-017765.full
AB  - Background Futile recanalization—when patients have a successful recanalization but fail to achieve a satisfactory functional outcome— is a common phenomenon of endovascular treatment of acute ischemic stroke (AIS). The present study aimed to identify the predictors of futile recanalization in AIS patients who received endovascular treatment.Methods This is a post-hoc analysis of the DIRECT-MT trial. Demographics, clinical characteristics, acute stroke workflow interval times, biochemical parameters, and imaging characteristics were compared between futile and meaningful recanalization groups. Multivariate analysis was performed to identify the predictors of futile recanalization.Results Futile recanalization was observed in 277 patients. In multivariable logistic regression analysis, older age (p<0.001), higher baseline systolic blood pressure (SBP) (p=0.032), incomplete reperfusion defined by extended Thrombolysis In Cerebral Infarction (eTICI) grades (p=0.020), and larger final infarct volume (FIV) (p<0.001) were independent predictors of futile recanalization.Conclusions Old age, high baseline SBP, incomplete reperfusion defined by eTICI, and large FIV were independent predictors of futile recanalization after endovascular therapy for AIS.Data are available in a public, open access repository. All free text entered below will be published.