RT Journal Article
SR Electronic
T1 Predictors of futile recanalization in patients undergoing endovascular treatment in the DIRECT-MT trial
JF Journal of NeuroInterventional Surgery
JO J NeuroIntervent Surg
FD BMJ Publishing Group Ltd.
SP neurintsurg-2021-017765
DO 10.1136/neurintsurg-2021-017765
A1 Tengfei Zhou
A1 Tingyu Yi
A1 Tianxiao Li
A1 Liangfu Zhu
A1 Yucheng Li
A1 Zhaoshuo Li
A1 Meiyun Wang
A1 Qiang Li
A1 Yingkun He
A1 Pengfei Yang
A1 Yongwei Zhang
A1 Zifu Li
A1 Yongxin Zhang
A1 Xiaofei Ye
A1 Wenhuo Chen
A1 Shouchun Wang
A1 Jianmin Liu
A1 ,
YR 2021
UL http://jnis.bmj.com/content/early/2021/09/02/neurintsurg-2021-017765.abstract
AB Background Futile recanalization—when patients have a successful recanalization but fail to achieve a satisfactory functional outcome— is a common phenomenon of endovascular treatment of acute ischemic stroke (AIS). The present study aimed to identify the predictors of futile recanalization in AIS patients who received endovascular treatment.Methods This is a post-hoc analysis of the DIRECT-MT trial. Demographics, clinical characteristics, acute stroke workflow interval times, biochemical parameters, and imaging characteristics were compared between futile and meaningful recanalization groups. Multivariate analysis was performed to identify the predictors of futile recanalization.Results Futile recanalization was observed in 277 patients. In multivariable logistic regression analysis, older age (p<0.001), higher baseline systolic blood pressure (SBP) (p=0.032), incomplete reperfusion defined by extended Thrombolysis In Cerebral Infarction (eTICI) grades (p=0.020), and larger final infarct volume (FIV) (p<0.001) were independent predictors of futile recanalization.Conclusions Old age, high baseline SBP, incomplete reperfusion defined by eTICI, and large FIV were independent predictors of futile recanalization after endovascular therapy for AIS.Data are available in a public, open access repository. All free text entered below will be published.