TY - JOUR T1 - Non-ischemic cerebral enhancing lesions after intracranial aneurysm endovascular repair: a retrospective French national registry JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg DO - 10.1136/neurintsurg-2021-017992 SP - neurintsurg-2021-017992 AU - Eimad Shotar AU - Marc-Antoine Labeyrie AU - Alessandra Biondi AU - Stéphane Velasco AU - Guillaume Saliou AU - Grégoire Boulouis AU - Benjamin Daumas-Duport AU - Romain Bourcier AU - Kevin Janot AU - Denis Herbreteau AU - Caterina Michelozzi AU - Kevin Premat AU - Hocine Redjem AU - Nicolas Bricout AU - Pierre Thouant AU - Charles Arteaga AU - Laurent Pierot AU - Florence Tahon AU - Kamel Boubagra AU - Leon Ikka AU - Emmanuel Chabert AU - Stéphanie Lenck AU - Alexis Guédon AU - Arturo Consoli AU - Suzana Saleme AU - Federico di Maria AU - Jean-Christophe Ferré AU - Francois Eugene AU - René Anxionnat AU - Gaultier Marnat AU - Zakaria Guetarni AU - Nader-Antoine Sourour AU - Didier Dormont AU - Frédéric Clarençon Y1 - 2021/09/20 UR - http://jnis.bmj.com/content/early/2021/09/20/neurintsurg-2021-017992.abstract N2 - Background Non-ischemic cerebral enhancing (NICE) lesions are exceptionally rare following aneurysm endovascular therapy (EVT).Objective To investigate the presenting features and longitudinal follow-up of patients with NICE lesions following aneurysm EVT.Methods Patients included in a retrospective national multicentre inception cohort were analysed. NICE lesions were defined, using MRI, as delayed onset punctate, nodular or annular foci enhancements with peri-lesion edema, distributed in the vascular territory of the aneurysm EVT, with no other confounding disease.Results From a pool of 58 815 aneurysm endovascular treatment procedures during the study sampling period (2006–2019), 21/37 centres identified 31 patients with 32 aneurysms of the anterior circulation who developed NICE lesions (mean age 45±10 years). Mean delay to diagnosis was 5±9 months, with onset occurring a month or less after the index EVT procedure in 10 out of 31 patients (32%). NICE lesions were symptomatic at time of onset in 23 of 31 patients (74%). After a mean follow-up of 25±26 months, 25 patients (81%) were asymptomatic or minimally symptomatic without disability (modified Rankin Scale (mRS) score 0–1) at last follow-up while 4 (13%) presented with mild disability (mRS score 2). Clinical follow-up data were unavailable for two patients. Follow-up MRI (available in 27 patients; mean time interval after onset of 22±22 months) demonstrated persistent enhancement in 71% of cases.Conclusions The clinical spectrum of NICE lesions following aneurysm EVT therapy spans a wide range of neurological symptoms. Clinical course is most commonly benign, although persistent long-term enhancement is frequent.Data are available upon reasonable request. ER -