PT  - JOURNAL ARTICLE
AU  - Michal Zawadzki
AU  - Jerzy Walecki
AU  - Boguslaw Kostkiewicz
AU  - Kacper Kostyra
AU  - Piotr Walczak
AU  - Miroslaw Janowski
TI  - Follow-up of intra-arterial delivery of bevacizumab for treatment of butterfly glioblastoma in patient with first-in-human, real-time MRI-guided intra-arterial neurointervention
AID  - 10.1136/neurintsurg-2021-017900
DP  - 2021 Nov 01
TA  - Journal of NeuroInterventional Surgery
PG  - 1037--1039
VI  - 13
IP  - 11
4099  - http://jnis.bmj.com/content/13/11/1037.short
4100  - http://jnis.bmj.com/content/13/11/1037.full
SO  - J NeuroIntervent Surg2021 Nov 01; 13
AB  - This case report shows that real-time MRI may aid in the precision of intra-arterial delivery of bevacizumab to butterfly glioblastoma. Fast clinical improvement, decrease of contrast enhancing status, and no serious adverse effects were observed at discharge from hospital. The patient regained pre-recurrent neurological status for 2 months with a subsequent fast clinical decline and an increase in tumor volume. The patient underwent a second procedure of intra-arterial delivery of bevacizumab to the brain, with substantial clinical and radiological improvement, but not the level of improvement observed after the first procedure. Another clinical decline occurred with an increase in tumor size and the patient was treated 2 months later with a third intra-arterial infusion of bevacizumab. While another positive effect was achieved, it was less pronounced than before, and the patient died 1.5 months later. There were no technical, ischemic or other complications during the procedures. The patient survived 218 days from the first symptoms of tumor recurrence, 190 days from the first MRI, and 175 days from the first intra-arterial treatment of bevacizumab.