TY - JOUR T1 - Identifying large ischemic core volume ranges in acute stroke that can benefit from mechanical thrombectomy JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 1081 LP - 1087 DO - 10.1136/neurintsurg-2020-016934 VL - 13 IS - 12 AU - Takeshi Yoshimoto AU - Manabu Inoue AU - Kanta Tanaka AU - Kodai Kanemaru AU - Junpei Koge AU - Masayuki Shiozawa AU - Naruhiko Kamogawa AU - Shunsuke Kimura AU - Tetsuya Chiba AU - Tetsu Satow AU - Jun C Takahashi AU - Kazunori Toyoda AU - Masatoshi Koga AU - Masafumi Ihara Y1 - 2021/12/01 UR - http://jnis.bmj.com/content/13/12/1081.abstract N2 - Background We aimed to identify the large ischemic core (LIC) volume ranges in acute ischemic stroke patients that can benefit from mechanical thrombectomy (MT).Methods Consecutive patients within 24 hours of onset of anterior circulation ischemic stroke with large vessel occlusion and ischemic core volumes of 70–300 mL were included from our single-center prospective database from March 2014 to December 2019. Subjects were divided into three groups by baseline ischemic core volume (A: 70–100 mL; B: 101–130 mL; C: >130 mL). We compared modified Rankin Scale (mRS) score 0–2 at 3 months and parenchymal hematoma between patients receiving MT and standard medical treatment (SMT), and determined clinically treatable core volume ranges for MT.Results Of 157 patients (86 women; median age, 81 years; median ischemic core volume, 123 mL), 49 patients underwent MT. In Group A (n=52), MT patients (n=31) showed a higher proportion of mRS 0–2 at 3 months (52% vs 5%, P<0.05) versus SMT, respectively. Group B (n=36) MT patients (n=14) also had a higher proportion of mRS 0–2 at 3 months (29% vs 9%, P=0.13) versus SMT, respectively. In Group C (n=69), only four patients received MT. The 95% confidence intervals for the probability of mRS 0–2 at 3 months in patients with MT (n=49) versus SMT (n=108) intersected at 120–130 mL.Conclusions Ischemic core volumes between 70 and 100 mL may benefit from MT. The treatable upper core limit is approximately 120 mL in selected patients with LIC of 70–300 mL.Data are available in a public, open access repository. Data are available upon reasonable request. The NCVC Stroke Registry is always available. ER -