RT Journal Article
SR Electronic
T1 First-in-human endovascular treatment of hydrocephalus with a miniature biomimetic transdural shunt
JF Journal of NeuroInterventional Surgery
JO J NeuroIntervent Surg
FD BMJ Publishing Group Ltd.
SP neurintsurg-2021-018136
DO 10.1136/neurintsurg-2021-018136
A1 Pedro Lylyk
A1 Ivan Lylyk
A1 Carlos Bleise
A1 Esteban Scrivano
A1 Pedro Nicolas Lylyk
A1 Brandon Beneduce
A1 Carl B Heilman
A1 Adel M Malek
YR 2021
UL http://jnis.bmj.com/content/early/2021/12/02/neurintsurg-2021-018136.abstract
AB Surgical ventriculoperitoneal shunting remains standard treatment for communicating hydrocephalus, despite persistently elevated infection and revision rates. A novel minimally invasive endovascular cerebrospinal fluid (CSF) shunt was developed to mimic the function of the arachnoid granulation which passively filters CSF from the central nervous system back into the intracranial venous sinus network. The endovascular shunt is deployed via a femoral transvenous approach across the dura mater into the cerebellopontine angle cistern. An octogenarian with intractable hydrocephalus following subarachnoid hemorrhage underwent successful endovascular shunting, resulting in swift intracranial pressure reduction from 38 to <20 cmH2O (<90 min) and resolution of ventriculomegaly. This first successful development of a percutaneous transluminal venous access to the central nervous system offers a new pathway for non-invasive treatment of hydrocephalus and the potential for intervention against neurological disorders.