RT Journal Article SR Electronic T1 Clinical outcomes of rescue stenting for failed endovascular thrombectomy: a multicenter prospective registry JF Journal of NeuroInterventional Surgery JO J NeuroIntervent Surg FD BMJ Publishing Group Ltd. SP neurintsurg-2021-018308 DO 10.1136/neurintsurg-2021-018308 A1 Jang-Hyun Baek A1 Byung Moon Kim A1 Eun Hyun Ihm A1 Chang-Hyun Kim A1 Dong Joon Kim A1 Ji Hoe Heo A1 Hyo Suk Nam A1 Young Dae Kim A1 Sangil Suh A1 Byungjun Kim A1 Yoodong Won A1 Byung Hyun Baek A1 Woong Yoon A1 Hyon-Jo Kwon A1 Yoonkyung Chang A1 Cheolkyu Jung A1 Hae Woong Jeong YR 2022 UL http://jnis.bmj.com/content/early/2022/01/11/neurintsurg-2021-018308.abstract AB Background Mechanical thrombectomy (MT) is a primary endovascular modality for acute intracranial large vessel occlusion. However, further treatment, such as rescue stenting, is occasionally necessary for refractory cases. We aimed to investigate the efficacy and safety of rescue stenting in first-line MT failure and to identify the clinical factors affecting its clinical outcome.Methods A multicenter prospective registry was designed for this study. We enrolled consecutive patients who underwent rescue stenting for first-line MT failure. Endovascular details and outcomes, follow-up patency of the stented artery, and clinical outcomes were summarized and compared between the favorable and unfavorable outcome groups.Results A total of 78 patients were included. Intracranial atherosclerotic stenosis was the most common etiology for rescue stenting (97.4%). Seventy-seven patients (98.7%) were successfully recanalized by rescue stenting. A favorable outcome was observed in 66.7% of patients. Symptomatic intracranial hemorrhage and mortality were observed in 5.1% and 4.0% of patients, respectively. The stented artery was patent in 82.1% of patients on follow-up angiography. In a multivariable analysis, a patent stent on follow-up angiography was an independent factor for a favorable outcome (OR 87.6; 95% CI 4.77 to 1608.9; p=0.003). Postprocedural intravenous maintenance of glycoprotein IIb/IIIa inhibitor was significantly associated with the follow-up patency of the stented artery (OR 5.72; 95% CI 1.45 to 22.6; p=0.013).Conclusions In this multicenter prospective registry, rescue stenting for first-line MT failure was effective and safe. For a favorable outcome, follow-up patency of the stented artery was important, which was significantly associated with postprocedural maintenance of glycoprotein IIb/IIIa inhibitors.Data are available upon reasonable request. The relevant anonymized data are available on reasonable request.