TY - JOUR T1 - Treatment of experimental aneurysms with a GPX embolic agent prototype: preliminary angiographic and histological results JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 286 LP - 290 DO - 10.1136/neurintsurg-2021-017308 VL - 14 IS - 3 AU - Frederik Fries AU - Toshiki Tomori AU - Walter J Schulz-Schaeffer AU - Joshua Jones AU - Umut Yilmaz AU - Michael Kettner AU - Andreas Simgen AU - Wolfgang Reith AU - Ruben Mühl-Benninghaus Y1 - 2022/03/01 UR - http://jnis.bmj.com/content/14/3/286.abstract N2 - Background Recently, liquid embolic agents have emerged for the endovascular treatment of cerebral aneurysms. Here we describe the in vivo performance of a novel liquid embolization agent (GPX Embolic Device).Methods Elastase-induced aneurysms were embolized with a GPX prototype under balloon assistance. Digital subtraction angiography was performed pre-deployment and immediately after, and at 5, 10, and 30 min post-deployment in 10 rabbits and at 1 month in 8 rabbits. The early post-deployment intra-aneurysmal flow was graded as unchanged, moderately diminished, or completely absent. At 1 month the status of aneurysm occlusion was evaluated. Adhesion to catheter material and migration of GPX was assessed.Results The mean aneurysm neck diameter, width, and height were 3.6±1.0 mm, 3.0±0.8 mm, and 7.4±1.4 mm, respectively. The mean dome-to-neck ratio was 0.9±0.2. Complete stagnation of intra-aneurysmal flow was observed in 9 of 10 aneurysms (90%) within 30 min of device deployment. One aneurysm showed moderately diminished intra-aneurysmal flow at 30 min. At 1 month, 8 aneurysms were completely occluded. There was no evidence of GPX adhesion to the catheter material. Histologically, a leukocyte and foreign body reaction to GPX was detectable 28 days after embolization.Conclusions This is the first preclinical study reporting the performance of a protype version of the GPX Embolic Device in a wide-neck aneurysm model. GPX showed promising results by achieving and maintaining high rates of complete angiographic occlusion, but may induce an inflammatory reaction.All data relevant to the study are included in the article or uploaded as supplementary information. ER -