TY - JOUR T1 - Endovascular reperfusion of M2 occlusions in acute ischemic stroke reduced disability and mortality: ETIS Registry results JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 444 LP - 449 DO - 10.1136/neurintsurg-2021-017380 VL - 14 IS - 5 AU - Patricio Muszynski AU - Mohammad Anadani AU - Sébastien Richard AU - Gaultier Marnat AU - Romain Bourcier AU - Igor Sibon AU - Cyril Dargazanli AU - Caroline Arquizan AU - Benjamin Maïer AU - Raphaël Blanc AU - Bertrand Lapergue AU - Arturo Consoli AU - Francois Eugene AU - Stephane Vannier AU - Laurent Spelle AU - Christian Denier AU - Marion Boulanger AU - Maxime Gauberti AU - Suzana Saleme AU - Francisco Macian AU - Frédéric Clarençon AU - Charlotte Rosso AU - Olivier Naggara AU - Guillaume Turc AU - Ozlem Ozkul-Wermester AU - Chrisanthi Papagiannaki AU - Alain Viguier AU - Christophe Cognard AU - Anthony Le Bras AU - Sarah Evain AU - Valérie Wolff AU - Raoul Pop AU - Serge Timsit AU - Jean-Christophe Gentric AU - Frédéric Bourdain AU - Louis Veunac AU - Benjamin Gory AU - Stephanos Nikolaos Finitsis A2 - , Y1 - 2022/05/01 UR - http://jnis.bmj.com/content/14/5/444.abstract N2 - Background The predictors of successful reperfusion and the effect of reperfusion after endovascular treatment (EVT) for M2 occlusions have not been well studied. We aimed to identify predictors of successful reperfusion and the effect of reperfusion on outcomes of EVT for M2 occlusions in current practice.Methods Patients with acute ischemic stroke due to isolated M2 occlusions who were enrolled in the prospective multicenter Endovascular Treatment in Ischemic Stroke (ETIS) Registry in France between January 2015 and March 2020 were included. The primary outcome was a favorable outcome, defined as modified Rankin Scale (mRS) score of 0–2 at 90 days. Successful reperfusion was defined as an improvement of ≥1 points in the modified Thrombolysis In Cerebral Infarction score between the first and the last intracranial angiogram.Results A total of 458 patients were included (median National Institutes of Health Stroke Scale (NIHSS) score 14; 61.4% received prior intravenous thrombolysis). Compared with the non-reperfused patients, reperfused patients had an increased rate of excellent outcome (OR 2.3, 95% CI 0.98 to 5.36; p=0.053), favorable outcome (OR 2.79, 95% CI 1.31 to 5.93; p=0.007), and reduced 90-day mortality (OR 0.39, 95% CI 0.19 to 0.79; p<0.01). Admission NIHSS score was the only predictor of successful reperfusion. First-line strategy was not a predictor of successful reperfusion or favorable outcome, but the use of a stent retriever, alone or with an aspiration catheter, was associated with higher rates of procedural complications and 90-day mortality.Conclusions Successful reperfusion of M2 occlusions reduced disability and mortality. However, safety is a concern, especially if the procedure failed.All data relevant to the study are included in the article or uploaded as supplemental information. Endovascular Treatment in Ischemic Stroke (ETIS) Investigators. ER -