RT Journal Article
SR Electronic
T1 CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS): 12-month angiographic results of a multicenter study
JF Journal of NeuroInterventional Surgery
JO J NeuroIntervent Surg
FD BMJ Publishing Group Ltd.
SP neurintsurg-2022-018749
DO 10.1136/neurintsurg-2022-018749
A1 Laurent Spelle
A1 Denis Herbreteau
A1 Jildaz Caroff
A1 Xavier Barreau
A1 Jean-Christophe Ferré
A1 Jens Fiehler
A1 Anne-Christine Januel
A1 Vincent Costalat
A1 Thomas Liebig
A1 Romain Bourcier
A1 Markus A Möhlenbruch
A1 Joachim Berkefeld
A1 Werner Weber
A1 Cristian Mihalea
A1 Léon Ikka
A1 Augustin Ozanne
A1 Christophe Cognard
A1 Ana Paula Narata
A1 Richard Edwige Bibi
A1 Jean-Yves Gauvrit
A1 Hélène Raoult
A1 Stéphane Velasco
A1 Jan-Hendrik Buhk
A1 Vanessa Chalumeau
A1 Maxim Bester
A1 Hubert Desal
A1 Richard du Mesnil de Rochemont
A1 Georg Bohner
A1 Sebastian Fischer
A1 Sophie Gallas
A1 Alessandra Biondi
A1 Lamiae Grimaldi
A1 Jacques Moret
A1 James Byrne
A1 Laurent Pierot
YR 2022
UL http://jnis.bmj.com/content/early/2022/07/26/neurintsurg-2022-018749.abstract
AB Background The CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS) study has shown that the endovascular treatment of ruptured bifurcation aneurysms with the Woven EndoBridge (WEB) is safe and effective and provides protection against rebleeding at 1 month and 1 year. The 12-month angiographic follow-up is an important endpoint of the study.Methods The CLARYS study is a prospective multicenter study conducted in 13 European centers. The study enrolled 60 patients with 60 ruptured aneurysms of the anterior and posterior circulation. The study was conducted with an independent assessment of safety outcomes and imaging.Results Sixty patients with 60 ruptured bifurcation aneurysms to be treated with the WEB were included. Fifty-three aneurysms (88.3%) had a broad base with a dome to neck ratio <2 (mean 1.6). Of these, 46 patients were evaluated by an independent core laboratory with follow-up imaging performed at 12 months or before eventual retreatment. At 1 year, 19/46 aneurysms (41.3%) were completely occluded (Raymond–Roy grade I), 21/46 (45.7%) had a residual neck and 6/46 (13.0%) had residual aneurysm filling. Adequate occlusion was reported in 40/46 (87%) aneurysms. Six patients underwent target aneurysm retreatment.Conclusions The CLARYS study has previously shown that the use of the WEB in the endovascular treatment of ruptured bifurcation aneurysms provides effective protection against rebleeding with a good safety profile. The angiographic occlusion rates at 1 year reported here are comparable to those already seen in previous multicenter studies which primarily included unruptured aneurysms.Data are available upon reasonable request.