TY - JOUR T1 - CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS): 12-month angiographic results of a multicenter study JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg DO - 10.1136/neurintsurg-2022-018749 SP - neurintsurg-2022-018749 AU - Laurent Spelle AU - Denis Herbreteau AU - Jildaz Caroff AU - Xavier Barreau AU - Jean-Christophe Ferré AU - Jens Fiehler AU - Anne-Christine Januel AU - Vincent Costalat AU - Thomas Liebig AU - Romain Bourcier AU - Markus A Möhlenbruch AU - Joachim Berkefeld AU - Werner Weber AU - Cristian Mihalea AU - Léon Ikka AU - Augustin Ozanne AU - Christophe Cognard AU - Ana Paula Narata AU - Richard Edwige Bibi AU - Jean-Yves Gauvrit AU - Hélène Raoult AU - Stéphane Velasco AU - Jan-Hendrik Buhk AU - Vanessa Chalumeau AU - Maxim Bester AU - Hubert Desal AU - Richard du Mesnil de Rochemont AU - Georg Bohner AU - Sebastian Fischer AU - Sophie Gallas AU - Alessandra Biondi AU - Lamiae Grimaldi AU - Jacques Moret AU - James Byrne AU - Laurent Pierot Y1 - 2022/07/26 UR - http://jnis.bmj.com/content/early/2022/07/26/neurintsurg-2022-018749.abstract N2 - Background The CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS) study has shown that the endovascular treatment of ruptured bifurcation aneurysms with the Woven EndoBridge (WEB) is safe and effective and provides protection against rebleeding at 1 month and 1 year. The 12-month angiographic follow-up is an important endpoint of the study.Methods The CLARYS study is a prospective multicenter study conducted in 13 European centers. The study enrolled 60 patients with 60 ruptured aneurysms of the anterior and posterior circulation. The study was conducted with an independent assessment of safety outcomes and imaging.Results Sixty patients with 60 ruptured bifurcation aneurysms to be treated with the WEB were included. Fifty-three aneurysms (88.3%) had a broad base with a dome to neck ratio <2 (mean 1.6). Of these, 46 patients were evaluated by an independent core laboratory with follow-up imaging performed at 12 months or before eventual retreatment. At 1 year, 19/46 aneurysms (41.3%) were completely occluded (Raymond–Roy grade I), 21/46 (45.7%) had a residual neck and 6/46 (13.0%) had residual aneurysm filling. Adequate occlusion was reported in 40/46 (87%) aneurysms. Six patients underwent target aneurysm retreatment.Conclusions The CLARYS study has previously shown that the use of the WEB in the endovascular treatment of ruptured bifurcation aneurysms provides effective protection against rebleeding with a good safety profile. The angiographic occlusion rates at 1 year reported here are comparable to those already seen in previous multicenter studies which primarily included unruptured aneurysms.Data are available upon reasonable request. ER -