PT - JOURNAL ARTICLE AU - Jang, Seong Hwa AU - Park, Hyungjong AU - Yoo, Joonsang AU - Hong, Jeong-Ho AU - Lee, Jin Soo AU - Lee, Seong-Joon AU - Kim, Yong-Won AU - Hong, Ji Man AU - Choi, Jin Wook AU - Kang, Dong-Hun AU - Kim, Yong-Sun AU - Hwang, Yang-Ha AU - Sohn, Sung-Il TI - Intracranial non-occlusive intraluminal thrombus may indicate underlying etiology of large vessel occlusion in patients undergoing endovascular therapy AID - 10.1136/neurintsurg-2021-017995 DP - 2022 Oct 01 TA - Journal of NeuroInterventional Surgery PG - 997--1001 VI - 14 IP - 10 4099 - http://jnis.bmj.com/content/14/10/997.short 4100 - http://jnis.bmj.com/content/14/10/997.full SO - J NeuroIntervent Surg2022 Oct 01; 14 AB - Background The underlying etiology of intracranial non-occlusive intraluminal thrombus (iNOT) remains unknown. This study aimed to investigate whether the presence of iNOT can indicate the underlying etiology of large vessel occlusion (LVO) in patients undergoing endovascular therapy (EVT).Methods Among patients who underwent EVT at three comprehensive stroke centers, we included those with intracranial LVO in the anterior circulation. The presence of iNOT was determined by pretreatment DSA. We investigated the association between iNOT and intracranial atherosclerotic stenosis (ICAS) related LVO.Results Of 546 patients, 44 (8.1%) had iNOT. Patients with iNOT were younger, had less hypertension, atrial fibrillation, and a history of antiplatelet use. In addition, the involvement of the M1 segment of the middle cerebral artery (MCA) was more frequent. However, they had a lower National Institutes of Health Stroke Scale (NIHSS) score on admission and longer onset to recanalization time compared with patients with no iNOT. In a logistic regression model adjusting for age, sex, atrial fibrillation, smoking, prior antiplatelet and anticoagulant use, intravenous tissue plasminogen activator, NIHSS on admission, number of technical trials, intraprocedural re-occlusion, and the location of LVO (p<0.10 in the univariate analysis), the presence of iNOT was significantly associated with ICAS related LVO (adjusted OR 3.04; 95% CI 1.33 to 6.90; p=0.007).Conclusions The presence of iNOT may reflect an underlying ICAS related LVO in patients undergoing EVT.Data are available upon reasonable request.