RT Journal Article
SR Electronic
T1 Intracranial non-occlusive intraluminal thrombus may indicate underlying etiology of large vessel occlusion in patients undergoing endovascular therapy
JF Journal of NeuroInterventional Surgery
JO J NeuroIntervent Surg
FD BMJ Publishing Group Ltd.
SP 997
OP 1001
DO 10.1136/neurintsurg-2021-017995
VO 14
IS 10
A1 Seong Hwa Jang
A1 Hyungjong Park
A1 Joonsang Yoo
A1 Jeong-Ho Hong
A1 Jin Soo Lee
A1 Seong-Joon Lee
A1 Yong-Won Kim
A1 Ji Man Hong
A1 Jin Wook Choi
A1 Dong-Hun Kang
A1 Yong-Sun Kim
A1 Yang-Ha Hwang
A1 Sung-Il Sohn
YR 2022
UL http://jnis.bmj.com/content/14/10/997.abstract
AB Background The underlying etiology of intracranial non-occlusive intraluminal thrombus (iNOT) remains unknown. This study aimed to investigate whether the presence of iNOT can indicate the underlying etiology of large vessel occlusion (LVO) in patients undergoing endovascular therapy (EVT).Methods Among patients who underwent EVT at three comprehensive stroke centers, we included those with intracranial LVO in the anterior circulation. The presence of iNOT was determined by pretreatment DSA. We investigated the association between iNOT and intracranial atherosclerotic stenosis (ICAS) related LVO.Results Of 546 patients, 44 (8.1%) had iNOT. Patients with iNOT were younger, had less hypertension, atrial fibrillation, and a history of antiplatelet use. In addition, the involvement of the M1 segment of the middle cerebral artery (MCA) was more frequent. However, they had a lower National Institutes of Health Stroke Scale (NIHSS) score on admission and longer onset to recanalization time compared with patients with no iNOT. In a logistic regression model adjusting for age, sex, atrial fibrillation, smoking, prior antiplatelet and anticoagulant use, intravenous tissue plasminogen activator, NIHSS on admission, number of technical trials, intraprocedural re-occlusion, and the location of LVO (p<0.10 in the univariate analysis), the presence of iNOT was significantly associated with ICAS related LVO (adjusted OR 3.04; 95% CI 1.33 to 6.90; p=0.007).Conclusions The presence of iNOT may reflect an underlying ICAS related LVO in patients undergoing EVT.Data are available upon reasonable request.