TY - JOUR T1 - Predictors of unfavorable outcome in stent-assisted coiling for symptomatic unruptured intracranial spontaneous vertebral artery dissecting aneurysms (uis-VADAs): results from a multicenter study JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 1008 LP - 1013 DO - 10.1136/neurintsurg-2021-017619 VL - 14 IS - 10 AU - Kaijun Zhao AU - Rui Zhao AU - Xinjian Yang AU - Sheng Guan AU - Guobiao Liang AU - Hong-Lei Wang AU - Donghai Wang AU - Wenfeng Feng AU - Zhenbao Li AU - Weiwei Wang AU - Ya Peng AU - Jing Xu AU - Lei Wang AU - Ming Zhong AU - Guohua Mao AU - Tianxiao Li AU - Yang Zhang AU - Dong Chen AU - Chuwei Cai AU - Xiaochuan Sun AU - Huaizhang Shi AU - Jianjun Yu AU - Yang Wang AU - Zhen Gu AU - Gang Zhu AU - Qing Zhu AU - Jieqing Wan AU - Qiuping Li AU - Hua Yang AU - Gang Li AU - Erqing Chai AU - Qiang Li AU - Pengfei Yang AU - Yibin Fang AU - Dongwei Dai AU - Bo Hong AU - Qinghai Huang AU - Yi Xu AU - Jianmin Liu AU - Jinyu Xu Y1 - 2022/10/01 UR - http://jnis.bmj.com/content/14/10/1008.abstract N2 - Objective To evaluate predictors of unfavorable outcome in stent-assisted coiling for symptomatic unruptured intracranial spontaneous vertebral artery dissecting aneurysms (uis-VADAs) based on 608 reconstructed lesions in 30 medical centres.Methods A total of 608 patients (male:female=479:129; mean age, 53.26±10.26 years) with 608 symptomatic uis-VADAs underwent reconstructive treatments using stent(s) with coils between January 2009 and December 2015. Treatments and predictors of unfavorable outcomes were retrospectively analyzed.Results Mainly, three methods were used to treat patients with uis-VADAs, including routine single-stent in 208 patients (such as Enterprise and others), new low-profile LVIS single stent in 107 patients, and multiple stents in 293 patients. During the median 66 months of clinical follow-up, 14 patients died, and 16 of the remaining 594 survivors had unfavorable outcomes (modified Rankin Scale score 3–5). The overall mortality rate was 2.3% (14/608), and the unfavorable outcome (mRS score 3–6) rate was 4.9% (30/608). Multivariate logistic regression analysis indicated that preprocedural ischemic infarctions (OR=3.78; 95% CI 1.52 to 9.40; p<0.01), diabetes mellitus (OR=3.74; 95% CI 1.31 to 10.68; p=0.01), and procedural complications (OR=14.18; 95% CI 5.47 to 36.80; p<0.01) were predictors of unfavorable outcome in the reconstructed VADAs.Conclusions This multicenter study indicated that preprocedural ischemic infarctions, diabetes mellitus, and procedural complications were related to unfavorable clinical outcomes in the reconstructed uis-VADAs.Data are available upon reasonable request. No. ER -