PT  - JOURNAL ARTICLE
AU  - Zhao, Kaijun
AU  - Zhao, Rui
AU  - Yang, Xinjian
AU  - Guan, Sheng
AU  - Liang, Guobiao
AU  - Wang, Hong-Lei
AU  - Wang, Donghai
AU  - Feng, Wenfeng
AU  - Li, Zhenbao
AU  - Wang, Weiwei
AU  - Peng, Ya
AU  - Xu, Jing
AU  - Wang, Lei
AU  - Zhong, Ming
AU  - Mao, Guohua
AU  - Li, Tianxiao
AU  - Zhang, Yang
AU  - Chen, Dong
AU  - Cai, Chuwei
AU  - Sun, Xiaochuan
AU  - Shi, Huaizhang
AU  - Yu, Jianjun
AU  - Wang, Yang
AU  - Gu, Zhen
AU  - Zhu, Gang
AU  - Zhu, Qing
AU  - Wan, Jieqing
AU  - Li, Qiuping
AU  - Yang, Hua
AU  - Li, Gang
AU  - Chai, Erqing
AU  - Li, Qiang
AU  - Yang, Pengfei
AU  - Fang, Yibin
AU  - Dai, Dongwei
AU  - Hong, Bo
AU  - Huang, Qinghai
AU  - Xu, Yi
AU  - Liu, Jianmin
AU  - Xu, Jinyu
TI  - Predictors of unfavorable outcome in stent-assisted coiling for symptomatic unruptured intracranial spontaneous vertebral artery dissecting aneurysms (uis-VADAs): results from a multicenter study
AID  - 10.1136/neurintsurg-2021-017619
DP  - 2022 Oct 01
TA  - Journal of NeuroInterventional Surgery
PG  - 1008--1013
VI  - 14
IP  - 10
4099  - http://jnis.bmj.com/content/14/10/1008.short
4100  - http://jnis.bmj.com/content/14/10/1008.full
SO  - J NeuroIntervent Surg2022 Oct 01; 14
AB  - Objective To evaluate predictors of unfavorable outcome in stent-assisted coiling for symptomatic unruptured intracranial spontaneous vertebral artery dissecting aneurysms (uis-VADAs) based on 608 reconstructed lesions in 30 medical centres.Methods A total of 608 patients (male:female=479:129; mean age, 53.26±10.26 years) with 608 symptomatic uis-VADAs underwent reconstructive treatments using stent(s) with coils between January 2009 and December 2015. Treatments and predictors of unfavorable outcomes were retrospectively analyzed.Results Mainly, three methods were used to treat patients with uis-VADAs, including routine single-stent in 208 patients (such as Enterprise and others), new low-profile LVIS single stent in 107 patients, and multiple stents in 293 patients. During the median 66 months of clinical follow-up, 14 patients died, and 16 of the remaining 594 survivors had unfavorable outcomes (modified Rankin Scale score 3–5). The overall mortality rate was 2.3% (14/608), and the unfavorable outcome (mRS score 3–6) rate was 4.9% (30/608). Multivariate logistic regression analysis indicated that preprocedural ischemic infarctions (OR=3.78; 95% CI 1.52 to 9.40; p<0.01), diabetes mellitus (OR=3.74; 95% CI 1.31 to 10.68; p=0.01), and procedural complications (OR=14.18; 95% CI 5.47 to 36.80; p<0.01) were predictors of unfavorable outcome in the reconstructed VADAs.Conclusions This multicenter study indicated that preprocedural ischemic infarctions, diabetes mellitus, and procedural complications were related to unfavorable clinical outcomes in the reconstructed uis-VADAs.Data are available upon reasonable request. No.