RT Journal Article
SR Electronic
T1 Predictors of unfavorable outcome in stent-assisted coiling for symptomatic unruptured intracranial spontaneous vertebral artery dissecting aneurysms (uis-VADAs): results from a multicenter study
JF Journal of NeuroInterventional Surgery
JO J NeuroIntervent Surg
FD BMJ Publishing Group Ltd.
SP 1008
OP 1013
DO 10.1136/neurintsurg-2021-017619
VO 14
IS 10
A1 Zhao, Kaijun
A1 Zhao, Rui
A1 Yang, Xinjian
A1 Guan, Sheng
A1 Liang, Guobiao
A1 Wang, Hong-Lei
A1 Wang, Donghai
A1 Feng, Wenfeng
A1 Li, Zhenbao
A1 Wang, Weiwei
A1 Peng, Ya
A1 Xu, Jing
A1 Wang, Lei
A1 Zhong, Ming
A1 Mao, Guohua
A1 Li, Tianxiao
A1 Zhang, Yang
A1 Chen, Dong
A1 Cai, Chuwei
A1 Sun, Xiaochuan
A1 Shi, Huaizhang
A1 Yu, Jianjun
A1 Wang, Yang
A1 Gu, Zhen
A1 Zhu, Gang
A1 Zhu, Qing
A1 Wan, Jieqing
A1 Li, Qiuping
A1 Yang, Hua
A1 Li, Gang
A1 Chai, Erqing
A1 Li, Qiang
A1 Yang, Pengfei
A1 Fang, Yibin
A1 Dai, Dongwei
A1 Hong, Bo
A1 Huang, Qinghai
A1 Xu, Yi
A1 Liu, Jianmin
A1 Xu, Jinyu
YR 2022
UL http://jnis.bmj.com/content/14/10/1008.abstract
AB Objective To evaluate predictors of unfavorable outcome in stent-assisted coiling for symptomatic unruptured intracranial spontaneous vertebral artery dissecting aneurysms (uis-VADAs) based on 608 reconstructed lesions in 30 medical centres.Methods A total of 608 patients (male:female=479:129; mean age, 53.26±10.26 years) with 608 symptomatic uis-VADAs underwent reconstructive treatments using stent(s) with coils between January 2009 and December 2015. Treatments and predictors of unfavorable outcomes were retrospectively analyzed.Results Mainly, three methods were used to treat patients with uis-VADAs, including routine single-stent in 208 patients (such as Enterprise and others), new low-profile LVIS single stent in 107 patients, and multiple stents in 293 patients. During the median 66 months of clinical follow-up, 14 patients died, and 16 of the remaining 594 survivors had unfavorable outcomes (modified Rankin Scale score 3–5). The overall mortality rate was 2.3% (14/608), and the unfavorable outcome (mRS score 3–6) rate was 4.9% (30/608). Multivariate logistic regression analysis indicated that preprocedural ischemic infarctions (OR=3.78; 95% CI 1.52 to 9.40; p<0.01), diabetes mellitus (OR=3.74; 95% CI 1.31 to 10.68; p=0.01), and procedural complications (OR=14.18; 95% CI 5.47 to 36.80; p<0.01) were predictors of unfavorable outcome in the reconstructed VADAs.Conclusions This multicenter study indicated that preprocedural ischemic infarctions, diabetes mellitus, and procedural complications were related to unfavorable clinical outcomes in the reconstructed uis-VADAs.Data are available upon reasonable request. No.