RT Journal Article SR Electronic T1 Predictors of unfavorable outcome in stent-assisted coiling for symptomatic unruptured intracranial spontaneous vertebral artery dissecting aneurysms (uis-VADAs): results from a multicenter study JF Journal of NeuroInterventional Surgery JO J NeuroIntervent Surg FD BMJ Publishing Group Ltd. SP 1008 OP 1013 DO 10.1136/neurintsurg-2021-017619 VO 14 IS 10 A1 Zhao, Kaijun A1 Zhao, Rui A1 Yang, Xinjian A1 Guan, Sheng A1 Liang, Guobiao A1 Wang, Hong-Lei A1 Wang, Donghai A1 Feng, Wenfeng A1 Li, Zhenbao A1 Wang, Weiwei A1 Peng, Ya A1 Xu, Jing A1 Wang, Lei A1 Zhong, Ming A1 Mao, Guohua A1 Li, Tianxiao A1 Zhang, Yang A1 Chen, Dong A1 Cai, Chuwei A1 Sun, Xiaochuan A1 Shi, Huaizhang A1 Yu, Jianjun A1 Wang, Yang A1 Gu, Zhen A1 Zhu, Gang A1 Zhu, Qing A1 Wan, Jieqing A1 Li, Qiuping A1 Yang, Hua A1 Li, Gang A1 Chai, Erqing A1 Li, Qiang A1 Yang, Pengfei A1 Fang, Yibin A1 Dai, Dongwei A1 Hong, Bo A1 Huang, Qinghai A1 Xu, Yi A1 Liu, Jianmin A1 Xu, Jinyu YR 2022 UL http://jnis.bmj.com/content/14/10/1008.abstract AB Objective To evaluate predictors of unfavorable outcome in stent-assisted coiling for symptomatic unruptured intracranial spontaneous vertebral artery dissecting aneurysms (uis-VADAs) based on 608 reconstructed lesions in 30 medical centres.Methods A total of 608 patients (male:female=479:129; mean age, 53.26±10.26 years) with 608 symptomatic uis-VADAs underwent reconstructive treatments using stent(s) with coils between January 2009 and December 2015. Treatments and predictors of unfavorable outcomes were retrospectively analyzed.Results Mainly, three methods were used to treat patients with uis-VADAs, including routine single-stent in 208 patients (such as Enterprise and others), new low-profile LVIS single stent in 107 patients, and multiple stents in 293 patients. During the median 66 months of clinical follow-up, 14 patients died, and 16 of the remaining 594 survivors had unfavorable outcomes (modified Rankin Scale score 3–5). The overall mortality rate was 2.3% (14/608), and the unfavorable outcome (mRS score 3–6) rate was 4.9% (30/608). Multivariate logistic regression analysis indicated that preprocedural ischemic infarctions (OR=3.78; 95% CI 1.52 to 9.40; p<0.01), diabetes mellitus (OR=3.74; 95% CI 1.31 to 10.68; p=0.01), and procedural complications (OR=14.18; 95% CI 5.47 to 36.80; p<0.01) were predictors of unfavorable outcome in the reconstructed VADAs.Conclusions This multicenter study indicated that preprocedural ischemic infarctions, diabetes mellitus, and procedural complications were related to unfavorable clinical outcomes in the reconstructed uis-VADAs.Data are available upon reasonable request. No.