RT Journal Article
SR Electronic
T1 Predictors of unfavorable outcome in stent-assisted coiling for symptomatic unruptured intracranial spontaneous vertebral artery dissecting aneurysms (uis-VADAs): results from a multicenter study
JF Journal of NeuroInterventional Surgery
JO J NeuroIntervent Surg
FD BMJ Publishing Group Ltd.
SP 1008
OP 1013
DO 10.1136/neurintsurg-2021-017619
VO 14
IS 10
A1 Kaijun Zhao
A1 Rui Zhao
A1 Xinjian Yang
A1 Sheng Guan
A1 Guobiao Liang
A1 Hong-Lei Wang
A1 Donghai Wang
A1 Wenfeng Feng
A1 Zhenbao Li
A1 Weiwei Wang
A1 Ya Peng
A1 Jing Xu
A1 Lei Wang
A1 Ming Zhong
A1 Guohua Mao
A1 Tianxiao Li
A1 Yang Zhang
A1 Dong Chen
A1 Chuwei Cai
A1 Xiaochuan Sun
A1 Huaizhang Shi
A1 Jianjun Yu
A1 Yang Wang
A1 Zhen Gu
A1 Gang Zhu
A1 Qing Zhu
A1 Jieqing Wan
A1 Qiuping Li
A1 Hua Yang
A1 Gang Li
A1 Erqing Chai
A1 Qiang Li
A1 Pengfei Yang
A1 Yibin Fang
A1 Dongwei Dai
A1 Bo Hong
A1 Qinghai Huang
A1 Yi Xu
A1 Jianmin Liu
A1 Jinyu Xu
YR 2022
UL http://jnis.bmj.com/content/14/10/1008.abstract
AB Objective To evaluate predictors of unfavorable outcome in stent-assisted coiling for symptomatic unruptured intracranial spontaneous vertebral artery dissecting aneurysms (uis-VADAs) based on 608 reconstructed lesions in 30 medical centres.Methods A total of 608 patients (male:female=479:129; mean age, 53.26±10.26 years) with 608 symptomatic uis-VADAs underwent reconstructive treatments using stent(s) with coils between January 2009 and December 2015. Treatments and predictors of unfavorable outcomes were retrospectively analyzed.Results Mainly, three methods were used to treat patients with uis-VADAs, including routine single-stent in 208 patients (such as Enterprise and others), new low-profile LVIS single stent in 107 patients, and multiple stents in 293 patients. During the median 66 months of clinical follow-up, 14 patients died, and 16 of the remaining 594 survivors had unfavorable outcomes (modified Rankin Scale score 3–5). The overall mortality rate was 2.3% (14/608), and the unfavorable outcome (mRS score 3–6) rate was 4.9% (30/608). Multivariate logistic regression analysis indicated that preprocedural ischemic infarctions (OR=3.78; 95% CI 1.52 to 9.40; p<0.01), diabetes mellitus (OR=3.74; 95% CI 1.31 to 10.68; p=0.01), and procedural complications (OR=14.18; 95% CI 5.47 to 36.80; p<0.01) were predictors of unfavorable outcome in the reconstructed VADAs.Conclusions This multicenter study indicated that preprocedural ischemic infarctions, diabetes mellitus, and procedural complications were related to unfavorable clinical outcomes in the reconstructed uis-VADAs.Data are available upon reasonable request. No.