@article {Dingneurintsurg-2022-019270, author = {Heyu Ding and Pengfei Zhao and Han Lv and Xiaoshuai Li and Xiaoyu Qiu and Chihang Dai and Ning Xu and Guopeng Wang and Zhenghan Yang and Shusheng Gong and Long Jin and Zhenchang Wang}, title = {A new method for assessing transverse sinus stenosis with CT venography based on the venous trans-stenotic pressure gradient}, elocation-id = {neurintsurg-2022-019270}, year = {2022}, doi = {10.1136/jnis-2022-019270}, publisher = {British Medical Journal Publishing Group}, abstract = {Background Evaluation of the transverse sinus stenosis (TSS) is essential for TSS-related diseases.Objective To investigate a new method for the quantitative assessment of TSS based on the correlation between TSS and trans-stenotic pressure gradient (TPG).Methods Patients with unilateral pulsatile tinnitus with or without idiopathic intracranial hypertension were retrospectively included. All patients underwent CT venography and venous manometry and were confirmed to have TSS. The cross-sectional diameter/area of TSS, the poststenotic and prestenotic segments, and the superior sagittal sinus (SSS) were measured. The degree of TSS was calculated by dividing the diameter/area of TSS by the diameter/area of the poststenotic segment (M1/M2), prestenotic segment (M3/M4), and SSS (M5/M6). Partial correlation analysis (controlling for the effect of age, sex, outflow laterality, and contralateral stenosis) was performed to evaluate the correlation between M1{\textendash}M6 and the TPG. Receiver operating characteristic curve analysis of M1{\textendash}M6 for diagnosing a significant TPG (>=8 mm Hg) was performed.Results Ninety-nine patients met the inclusion criteria. The partial correlation coefficients between M1{\textendash}M6 and the TPG were 0.60, 0.61, 0.43, 0.48, 0.39, and 0.54, respectively. The areas under the curve (AUCs) of M1{\textendash}M6 for diagnosing a significant TPG were 0.81, 0.86, 0.68, 0.69, 0.64, and 0.72, respectively. The AUC of M2 was significantly larger than that of M3 (P=0.002), M4 (P\<0.001), M5 (P=0.001), and M6 (P\<0.001).Conclusions Quantitatively assessing TSS by taking the ratio of the cross-sectional area of TSS to that of the poststenotic segment might be a more efficient method for predicting the TPG.All data relevant to the study are included in the article or uploaded as supplementary information.}, issn = {1759-8478}, URL = {https://jnis.bmj.com/content/early/2022/10/07/jnis-2022-019270}, eprint = {https://jnis.bmj.com/content/early/2022/10/07/jnis-2022-019270.full.pdf}, journal = {Journal of NeuroInterventional Surgery} }