TY - JOUR T1 - Systematic CT perfusion acquisition in acute stroke increases vascular occlusion detection and thrombectomy rates JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg SP - 1270 LP - 1273 DO - 10.1136/neurintsurg-2021-018241 VL - 14 IS - 12 AU - Marta Olive-Gadea AU - Manuel Requena AU - Facundo Diaz AU - Sandra Boned AU - Alvaro Garcia-Tornel AU - Marian Muchada AU - Matias Deck AU - Prudencio Lozano AU - Noelia Rodriguez-Villatoro AU - Jesus Juega AU - Jorge Pagola AU - David Rodriguez-Luna AU - Marta Rubiera AU - Cristian Marti AU - Carlos A Molina AU - Carlos Piñana AU - David Hernandez AU - Alejandro Tomasello AU - Marc Ribo Y1 - 2022/12/01 UR - http://jnis.bmj.com/content/14/12/1270.abstract N2 - Background In patients with stroke, current guidelines recommend non-invasive vascular imaging to identify intracranial vessel occlusions (VO) that may benefit from endovascular treatment (EVT). However, VO can be missed in CT angiography (CTA) readings. We aim to evaluate the impact of consistently including CT perfusion (CTP) in admission stroke imaging protocols.Methods From April to October 2020 all patients admitted with a suspected acute ischemic stroke underwent urgent non-contrast CT, CTA and CTP and were treated accordingly. Hypoperfusion areas defined by time-to-maximum of the tissue residue function (Tmax) >6 s, congruent with the clinical symptoms and a vascular territory, were considered VO (CTP-VO). In addition, two experienced neuroradiologists blinded to CTP but not to clinical symptoms retrospectively evaluated non-contrast CT and CTA to identify intracranial VO (CTA-VO).Results Of the 338 patients included in the analysis, 157 (46.5%) presented with CTP-VO (median Tmax >6s: 73 (29–127) mL). CTA-VO was identified in 83 (24.5%) of the cases. Overall CTA-VO sensitivity for the detection of CTP-VO was 50.3% and specificity was 97.8%. Higher hypoperfusion volume was associated with increased CTA-VO detection (OR 1.03; 95% CI 1.02 to 1.04). EVT was performed in 103 patients (30.5%; Tmax >6s: 102 (63–160) mL), representing 65.6% of all CTP-VO. Overall CTA-VO sensitivity for the detection of EVT-VO was 69.9% and specificity was 95.3%. Among patients who received EVT, the rate of false negative CTA-VO was 30.1% (Tmax >6s: 69 (46–99.5) mL).Conclusion Systematically including CTP in acute stroke admission imaging protocols may increase the diagnosis of VO and rate of EVT.Data are available upon reasonable request. Not applicable. ER -