@article {Koo255, author = {Andrew B Koo and Aladine A Elsamadicy and Daniela Renedo and Margot Sarkozy and Josiah Sherman and Benjamin C Reeves and John Havlik and Joseph Antonios and Nanthiya Sujijantarat and Ryan Hebert and Ajay Malhotra and Charles Matouk}, title = {Higher Hospital Frailty Risk Score is associated with increased complications and healthcare resource utilization after endovascular treatment of ruptured intracranial aneurysms}, volume = {15}, number = {3}, pages = {255--261}, year = {2023}, doi = {10.1136/neurintsurg-2021-018484}, publisher = {British Medical Journal Publishing Group}, abstract = {Aim To use the Hospital Frailty Risk Score (HFRS) to investigate the impact of frailty on complication rates and healthcare resource utilization in patients who underwent endovascular treatment of ruptured intracranial aneurysms (IAs).Methods A retrospective cohort study was performed using the 2016{\textendash}2019 National Inpatient Sample database. All adult patients (>=18 years) undergoing endovascular treatment for IAs after subarachnoid hemorrhage were identified using ICD-10-CM codes. Patients were categorized into frailty cohorts: low (HFRS \<5), intermediate (HFRS 5{\textendash}15) and high (HFRS \>15). Patient demographics, adverse events, length of stay (LOS), discharge disposition, and total cost of admission were assessed. Multivariate logistic regression analysis was used to identify independent predictors of prolonged LOS, increased cost, and non-routine discharge.Results Of the 33 840 patients identified, 7940 (23.5\%) were found to be low, 20 075 (59.3\%) intermediate and 5825 (17.2\%) high frailty by HFRS criteria. The rate of encountering any adverse event was significantly greater in the higher frailty cohorts (low: 59.9\%; intermediate: 92.4\%; high: 99.2\%, p\<0.001). There was a stepwise increase in mean LOS (low: 11.7{\textpm}8.2 days; intermediate: 18.7{\textpm}14.1 days; high: 26.6{\textpm}20.1 days, p\<0.001), mean total hospital cost (low: $62 888{\textpm}37 757; intermediate: $99 670{\textpm}63 446; high: $134 937{\textpm}80 331, p\<0.001), and non-routine discharge (low: 17.3\%; intermediate: 44.4\%; high: 69.4\%, p\<0.001) with increasing frailty. On multivariate regression analysis, a similar stepwise impact was found in prolonged LOS (intermediate: OR 2.38, p\<0.001; high: OR 4.49, p\<0.001)], total hospital cost (intermediate: OR 2.15, p\<0.001; high: OR 3.62, p\<0.001), and non-routine discharge (intermediate: OR 2.13, p\<0.001; high: OR 4.17, p\<0.001).Conclusions Our study found that greater frailty as defined by the HFRS was associated with increased complications, LOS, total costs, and non-routine discharge.All data relevant to the study are included in the article or uploaded as supplemental information. Not applicable.}, issn = {1759-8478}, URL = {https://jnis.bmj.com/content/15/3/255}, eprint = {https://jnis.bmj.com/content/15/3/255.full.pdf}, journal = {Journal of NeuroInterventional Surgery} }