RT Journal Article SR Electronic T1 Morphological characteristics associated with ruptured intracranial vertebral artery dissecting aneurysms JF Journal of NeuroInterventional Surgery JO J NeuroIntervent Surg FD BMJ Publishing Group Ltd. SP 321 OP 324 DO 10.1136/neurintsurg-2022-018744 VO 15 IS 4 A1 Jiangli Han A1 Jigang Chen A1 Xin Tong A1 Mingyang Han A1 Fei Peng A1 Hao Niu A1 Lang Liu A1 Fei Liu A1 Aihua Liu YR 2023 UL http://jnis.bmj.com/content/15/4/321.abstract AB Objective Morphological risk factors for the rupture of intracranial vertebral artery dissecting aneurysms (IVADAs) have not been well characterized. In this study, we aim to identify morphological characteristics associated with IVADA rupture.Methods We conducted a retrospective study of 249 consecutive patients with single IVADAs (31 ruptured and 218 unruptured) admitted to Beijing Tiantan Hospital between January 2016 and December 2020. Various morphological parameters were measured using three-dimensional digital subtraction angiography images. Univariate and multivariate logistic regression analyses were performed to identify morphological characteristics associated with IVADA rupture.Results Univariate regression analysis revealed that the coexistence of significant proximal and distal stenosis and posterior inferior cerebellar artery (PICA) involvement were associated with IVADA rupture, while the origin from the dominant vertebral artery was inversely associated with the rupture. Multivariate regression analysis demonstrated that the coexistence of significant proximal and distal stenosis (OR 22.00, 95% CI 5.60 to 86.70, p<0.001) and PICA involvement (OR 4.55, 95% CI 1.36 to 15.20, p=0.014) were independently associated with IVADA rupture.Conclusion The coexistence of significant proximal and distal stenosis and PICA involvement were independently associated with IVADA rupture. These morphological characteristics may facilitate the assessment of rupture risk in patients with IVADAs.Data are available upon reasonable request. The data supporting the findings of this study are available from the corresponding author upon reasonable request.