PT  - JOURNAL ARTICLE
AU  - Belanger, Brooke L
AU  - Morrish, Rosalie
AU  - McClarty, Davis
AU  - Barnstable, Colette
AU  - Muir, Warren
AU  - Ghazizadeh, Soheil
AU  - Eesa, Muneer
AU  - Fiorella, David
AU  - Wong, John H
AU  - Sadasivan, Chandar
AU  - Mitha, Alim P
TI  - In vitro flow diversion effect of the ReSolv stent with the shelf technique in a bifurcation aneurysm model
AID  - 10.1136/jnis-2022-020023
DP  - 2024 Mar 01
TA  - Journal of NeuroInterventional Surgery
PG  - 296--301
VI  - 16
IP  - 3
4099  - http://jnis.bmj.com/content/16/3/296.short
4100  - http://jnis.bmj.com/content/16/3/296.full
SO  - J NeuroIntervent Surg2024 Mar 01; 16
AB  - Background Flow-diverting stents are not currently indicated for the treatment of bifurcation aneurysms, and some case series have demonstrated low occlusion rates, possibly due to a lack in neck coverage. The ReSolv stent is a unique hybrid metal/polymer stent that can be deployed with the shelf technique in order to improve neck coverage.Methods A Pipeline, unshelfed ReSolv, and shelfed ReSolv stent were deployed in the left-sided branch of an idealized bifurcation aneurysm model. After determining stent porosity, high-speed digital subtraction angiography runs were acquired under pulsatile flow conditions. Time–density curves were created using two region of interest (ROI) paradigms (total aneurysm and left/right), and four parameters were extracted to characterize flow diversion performance.Results The shelfed ReSolv stent demonstrated better aneurysm outflow alterations compared to the Pipeline and unshelfed ReSolv stent when using the total aneurysm as the ROI. On the left side of the aneurysm, there was no significant difference between the shelfed ReSolv stent and the Pipeline. On the right side of the aneurysm, however, the shelfed ReSolv stent had a significantly better contrast washout profile than the unshelfed ReSolv stent and the Pipeline stent.Conclusions The ReSolv stent with the shelf technique demonstrates the potential to improve flow diversion outcomes for bifurcation aneurysms. Further in vivo testing will help to determine whether the additional neck coverage leads to better neointimal scaffolding and long-term aneurysm occlusion.Data are available upon reasonable request. Not Applicable.