RT Journal Article
SR Electronic
T1 Intravenous alteplase before endovascular therapy for acute large vessel occlusion with large ischemic core: subanalysis of a randomized clinical trial
JF Journal of NeuroInterventional Surgery
JO J NeuroIntervent Surg
FD BMJ Publishing Group Ltd.
SP 1094
OP 1100
DO 10.1136/jnis-2023-020846
VO 16
IS 11
A1 Shindo, Seigo
A1 Uchida, Kazutaka
A1 Yoshimura, Shinichi
A1 Sakai, Nobuyuki
A1 Yamagami, Hiroshi
A1 Toyoda, Kazunori
A1 Matsumaru, Yuji
A1 Matsumoto, Yasushi
A1 Kimura, Kazumi
A1 Ishikura, Reiichi
A1 Inoue, Manabu
A1 Sakakibara, Fumihiro
A1 Nakajima, Makoto
A1 Ueda, Mitsuharu
A1 Morimoto, Takeshi
YR 2024
UL http://jnis.bmj.com/content/16/11/1094.abstract
AB Background The efficacy of endovascular therapy (EVT) in patients with large ischemic core has been reported, but it remains unclear whether IV alteplase (IVT) has beneficial effects in addition to EVT in such patients. We evaluated the efficacy and safety of EVT with or without IVT.Methods The RESCUE-Japan LIMIT was an open-label, prospective, multicenter, randomized clinical trial to evaluate the efficacy and safety of EVT in stroke patients with large ischemic core, defined as Alberta Stroke Program Early CT Score (ASPECTS) 3–5. This subanalysis evaluated the differences in the effects of EVT with medical care (EVT group) compared with medical care alone (No-EVT group) between those who received IVT (IVT stratum) and those who did not (No-IVT stratum) before EVT.Results Among 202 enrolled patients, 147 (73%) did not receive IVT. In the No-IVT stratum, the modified Rankin Scale (mRS) score of 0–3 at 90 days was significantly higher in the EVT group than in the No-EVT group (31.1% vs 12.3%, OR 3.21 (95% CI 1.37 to 7.53)). In the IVT stratum, the mRS score of 0–3 was 30.8% in the EVT group and 13.8% in the No-EVT group (OR 2.78 (95% CI 0.72 to 10.7)) (interaction p=0.77). The incidence of symptomatic intracranial hemorrhage was not different between the two groups in the No-IVT stratum (OR 1.20 (95% CI 0.35 to 4.12)), but it was significantly higher in the EVT group than in the No-EVT group in the IVT stratum (11.5% vs 0%, p=0.03).Conclusions There was no difference in efficacy of EVT with or without IVT, while IVT before EVT might increase symptomatic intracranial hemorrhage in patients with large ischemic core.Trial registration information NCT03702413.The data that support the findings of this study are available from the corresponding author on reasonable request. Takeshi Morimoto had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.