Table 3

Variables predictive of ‘responders’ to vertebroplasty/kyphoplasty

Variable	All cancer patients (ACFs)		Cancer patients with MCFs
Variable	OR (95% CI)	p Value	OR (95% CI)	p Value
Univariate model (binary logit)
Sex (M vs F)	1.99 (0.34 to 11.78)	0.45	1.07 (0.13 to 9.21)	0.95
MCF (yes vs no)	2.23 (0.54 to 9.32)	0.27	NA	NA
Age (per 10 years)	1.17 (0.61 to 2.26)	0.63	1.79 (1.03 to 3.12)	0.04
Diagnosis
Breast cancer vs other	0.99 (0.17 to 6.29)	0.99	NA^*	NA^*
Lung cancer vs other	1.04 (0.15 to 7.63)	0.97
Multiple myeloma vs other	1.08 (0.15 to 6.70)	0.94
Vertebroplasty vs kyphoplasty	0.38 (0.09 to 1.52)	0.17	1.41 (0.14 to 14.48)	0.77
Both vs kyphoplasty	0.45 (0.16 to 1.22)	0.19	0.76 (0.20 to 2.95)	0.69
Needle approach
Bilateral vs unilateral	2.15 (0.54 to 8.50)	0.28	NA^†	NA^†
Both vs unilateral	2.69 (0.40 to 17.87)	0.31	NA^†	NA^†
No of levels treated	0.51 (0.15 to 1.70)	0.27	0.62 (0.13 to 2.93)	0.54
Region treated
Both vs thoracic	0.38 (0.13 to 1.12)	0.08	0.44 (0.11 to 1.85)	0.26
Lumbar vs thoracic	0.62 (0.21 to 1.84)	0.39	1.62 (0.44 to 6.00)	0.47
Age category	1.13 (0.53 to 2.39)	0.76	2.05 (1.07 to 3.94)	0.03
Radiation therapy (yes vs no)	1.22 (0.28 to 5.25)	0.79	1.22 (0.20 to 7.65)	0.83
Radiation time sequence (<6 months before the procedure vs <6 months after the procedure)^‡	0.59 (0.11 to 3.26)	0.55	0.82 (0.12 to 5.12)	0.83
Stepwise multiple logistic regression model
Documented MCF (yes vs no)	3.14 (0.78 to 12.62)	0.11	NA^§	NA^§
Age category	NA^§	NA^§	2.05 (1.07 to 3.94)	0.03
No of levels treated	0.43(0.14 to 1.33)	0.14	NA^§	NA^§

↵* Restricted to MCF only, among non-responders and using diagnosis=other as referent category, there are only three non-responders: two with breast cancer and one with lung cancer. There were not enough data to fit the logistic model.
↵† Restricted to MCF only, among non-responders and using approach=unilateral as the referent category, there are no subjects in any other category. There were not enough data to fit the logistic model.
↵‡ Among non-responders and using radiation time <6 months before procedure as referent category, there are only two subjects who were non-responders with radiation treatment time >6 months before the procedure one subject who was a non-responder with radiation treatment time >6 months after the procedure. There were not enough data to fit the logistic model for these two groups.
↵§ The multivariate stepwise model used the entire sample with entry criterion p=0.10. The results that fit this criterion for ACFs included documentation of MCF, number of levels treated and age category. Using MCF subjects only, the same procedure identified only age category as a variable that fit the entry criterion.
ACFs, all compression fractures; MCFs, metastatic compression fractures.