Table 4

Comparison with major acute stroke trials and major retrospective trials

Trial	No	Mean age (years)	Median NIHSS	Anterior circulation (%)	TTI (h)	Recanalization rates (TIMI 2–3) (%)	sICH (%)	Mortality (%)	Definition of favorable outcome	Favorable outcome (%)
Comparison with major trials
NINDS-I4	144	67	14	NA	<3	NA	6	17	mRS ≤1 at 90 days	47
NINDS-II4	168	69	14	NA	<3	NA	7		mRS ≤1 at 90 days	39
PROACT-II8	121	64	17	100	4.7 (median), <6	66	10.2	25	mRS ≤2 at 90 days	26
IMS-II6	81	64	19	100	2.7 (median), <6	60	9.9	16	mRS ≤2 at 90 days	46
Multi MERCI9	164	68	19	92	4.3 (median), <6	68	9.8	34	mRS ≤2 at 90 days	36
Penumbra7	21	60	21	57	<8	100	9.5	45	mRS ≤2 at 30 days	45
ECASS-III31	418	65	9	NA	4.0 (median), <6	NA	7.9	32	mRS ≤2 at 90 days	52.4
Tiwari et al	12	49.2	17	58.3	46 (median)	92	8	8	mRS ≤2 at 90 days	58
Comparison stent studies
Levy et al (SARIS)32	20	63	14	85	5.2	100	5	25	mRS ≤3 at discharge/30 days	60
Zaidat et al15	9	69	18	89	5.1	89	0	33	mRS ≤3 at 90 days	67
Levy et al14	19	60	16	79	3.5	79	0	32	mRS ≤3 at discharge/30 days	47
Sauveageau et al13	10	72.6	16.4	100	4.4	90	30	40	mRS ≤3 at discharge/30 days	30
Levy et al12	18	75.1	18	83	NA	83	17	39	mRS ≤3 at 90 days	22

ECASS, European Cooperative Acute Stroke Study; IMS, Interventional Management of Stroke; MERCI, Mechanical Embolus Removal in Cerebral Ischemia; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; NINDS, National Institute of Neurological Disorders and Stroke; PROACT, Prolyse in Acute Cerebral Thromboembolism; SARIS, Stent-Assisted Recanalization in Acute Ischemic Stroke; sICH, symptomatic intracranial hemorrhage; TIMI, Thrombolysis in Myocardial Infarction; TTI, time to intervention.