Table 2

Comparison of the current study with previous studies that treated ruptured wide necked aneurysms using stent

StudyNo of patientsAntiplatelet regimenIntraoperative rupture (n (%))Intracerebral hemorrhage (n (%))Thromboembolic eventStrokeEVD related complicationsOutcome
Jankowitz1341Intraoperative glycoprotein IIbIIIa antagonist followed by postoperative aspirin and clopidogrel. Standard use of heparin during procedure was maintained3 (4.5)2 (5)
  • Total=9 (10%)

  • Intraoperative=4 (3 resolved and 1 resulted in stroke)

  • Delayed in 5

5 with good outcome
  • Total events =9 catheter track punctuate hemorrhage =7 (3 clinically significant),

  • Large hemorrhage =2 (symptomatic in 1)

Described as good, but no clear specification was provided
Thantinen1461No standard antiplatelet regimen. Some received intraoperative acetylsalicylate and some received intraoperative heparin followed by aspirin and clopidogrel4 (7)Total events=7 (11%)Not describedNot described
  • Mortality 20%. Good outcome in 69% (GOS 5 and 4)

Lodi (current study)22Loading dose of 300 mg clopidogrel and aspirin at least 2 h prior to stent placement followed by 75 mg of clopidogrel and 325 mg aspirin daily for 4 weeks. All patients received intravenous heparin to obtain an activated coagulation time of 1.5–2 times baseline prior to stent deployment.00
  • Total events=2

  • Intraoperative non-occlusive stent thrombosis, 1 of which resolved spontaneously. Delayed symptomatic in 1 required intra-arterial administration of GPIIbIIIa receptor antagonist which resulted in complete resolution

00
  • No mortality. Good outcome 82% (GOS 5 in 17, GOS 4 in 1). Poor outcome 18% (GOS 3 in 4)

  • EVD, extraventricular drainage; GOS, Glasgow Outcome Scale.