Perioperative thromboembolic and hemorrhagic complications after treatment of cerebral aneurysms with the Pipeline Embolization Device (PED) by pre-procedure PRU value
| All perioperative complications | p Value† | Thromboembolic complications | p Value† | Hemorrhagic complications | p Value† | ||||
|---|---|---|---|---|---|---|---|---|---|
| All (%) | Major* (%) | All (%) | Major* (%) | All (%) | Major* (%) | ||||
| All procedures, n=48 | 8 (16.7) | 4 (8.3) | 4 (8.3) | 1 (2.1) | 4 (8.3) | 3 (6.3) | |||
| PRU<60 n=13 | 2 (15.4) | 2 (15.4) | 0 | 2 (15.4) | 2 (15.4) | ||||
| PRU 60–200 n=32 | 3 (9.4) | 0 | 2 (6.3) | 0 | 1 (3.1) | 0 | |||
| PRU>240 n=3 | 3 (100) | 2 (66.7) | <0.001/<0.001 | 2 (66.7) | 1 (33.3) | <0.001/<0.001 | 1‡ (33.3) | 1‡ (33.3) | 0.11/0.02 |
*Resulting in death or permanent disabling neurological deficit.
†For difference in all/major complications.
‡Patient death from large intracerebral hemorrhage ipsilateral to the Pipeline Embolization Device (PED) on postoperative day 4 in a clopidogrel hyporesponder (pre-procedure PRU 246) in whom the clopidogrel dose was increased to 150 mg before the PED procedure without rescheduling to a later date or retesting to assess the effect on the PRU value (PRU at the time of ICH was 10, figure 3).
n, number of procedures; PRU, P2Y12 reaction units.